Cited 189 times in
Involvement of aquaporins in colorectal carcinogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장윤수 | - |
dc.date.accessioned | 2015-07-15T16:54:20Z | - |
dc.date.available | 2015-07-15T16:54:20Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113832 | - |
dc.description.abstract | Aquaporins (AQPs) are important in controlling water permeability. As AQP1 is known as a serum-responsive gene, we hypothesized that AQP expression may be involved in the development of human cancer. By reverse transcriptase–polymerase chain reaction analysis, expression of AQPs 1, 3, and 5 was found in seven colon and colorectal cancer cell lines. Western blot analysis confirmed their expression in four of these cell lines. In situ hybridization demonstrated that during colorectal carcinogenesis, the expression of AQPs 1 and 5 was induced in early-stage disease (early dysplasia) and maintained through the late stages of colon cancer development. Expression of AQPs 1 and 5 was maintained even in metastatic lesions in the liver. These findings demonstrate that the expression of several AQPs is found in tumor cells and is associated with an early stage of colorectal cancer development. These novel observations suggest that multiple AQP expression may be advantageous to tumorigenesis, which may lead to a better understanding of colorectal carcinogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 6699~6703 | - |
dc.relation.isPartOf | ONCOGENE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aquaporin 1 | - |
dc.subject.MESH | Aquaporin 3 | - |
dc.subject.MESH | Aquaporin 5 | - |
dc.subject.MESH | Aquaporins/biosynthesis* | - |
dc.subject.MESH | Aquaporins/metabolism* | - |
dc.subject.MESH | Blood Group Antigens | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Membrane Proteins* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Involvement of aquaporins in colorectal carcinogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chulso Moon | - |
dc.contributor.googleauthor | Jean-Charles Soria | - |
dc.contributor.googleauthor | Li Mao | - |
dc.contributor.googleauthor | David Sidransky | - |
dc.contributor.googleauthor | Yoon Soo Chang | - |
dc.contributor.googleauthor | Barry Trink | - |
dc.contributor.googleauthor | Mathilde Sibony | - |
dc.contributor.googleauthor | Mohammad Obaidul Hoque | - |
dc.contributor.googleauthor | Juna Lee | - |
dc.contributor.googleauthor | Se Jin Jang | - |
dc.identifier.doi | 10.1038/sj.onc.1206762 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03456 | - |
dc.relation.journalcode | J02413 | - |
dc.identifier.eissn | 1476-5594 | - |
dc.identifier.pmid | 14555983 | - |
dc.identifier.url | http://www.nature.com/onc/journal/v22/n43/full/1206762a.html | - |
dc.subject.keyword | aquaporin | - |
dc.subject.keyword | in situ hybridization | - |
dc.subject.keyword | RT–PCR | - |
dc.subject.keyword | colon cancer | - |
dc.subject.keyword | carcinogenesis | - |
dc.contributor.alternativeName | Chang, Yoon Soo | - |
dc.contributor.affiliatedAuthor | Chang, Yoon Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 43 | - |
dc.citation.startPage | 6699 | - |
dc.citation.endPage | 6703 | - |
dc.identifier.bibliographicCitation | ONCOGENE, Vol.22(43) : 6699-6703, 2003 | - |
dc.identifier.rimsid | 41420 | - |
dc.type.rims | ART | - |
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