골반장기탈출증 발생에 있어서 에스트로겐 및 프로게스테론 수용체, P53,P21의 역할

Abstract

Objective : This study was carried out to compare the levels of estrogen receptor(ER), progesterone receptor(PR), p53 and p21 between pelvic organ prolapse(POP) and control groups in order to evaluate their roles in pathogenesis of pelvic organ prolapse, and if different, to find out the relationship among ER, PR, p53 and p21 patients. Materials and Methods : Between January 2002 and December 2002, uterosacral ligaments were obtained from 20 prolapsus(POP stage Ⅲ:10 and Ⅳ:10) and 24 non-prolapsus uteruses in patients who visited the urogynecologic clinic at Yonsei University Medical Center and had operations including total abdominal hysterectomy.?ER, PR, p53 and p21 proteins were extracted from the tissue in Western blot analysis and densitometric scanning was performed to compare relative levels of each protein. For statistical analysis, Student t-test and Pearson correlation coefficient were used. P value less than 0.05 was considered statistically significant. Results : The mean age and mean number of vaginal deliveries in the study group were 64.1 (8.1 years and 4.0 (2.2. The mean age and number of vaginal deliveries in the control group were 53.2 (3.6 years and 1.7 (1.0, which were lower than the prolapse group, but all patients in the study and control groups were postmenopausal and had never taken hormone replacement therapy. ER, PR, p53, and p21 were significantly lower in the prolapse group than control group(p＜0.0001), but no significant differences were observed between stage Ⅲ and Ⅳ prolapse groups. Positive correlations were found among all 4 protein levels in the prolapse group. Conclusion : ER, PR, p53 and p21 were significantly lower in the prolapse group. Further molecular researches are needed to elucidate the interrelationship among these proteins and their precise roles in pathogenesis of POP.