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Abstract

The amyloidosis combined with malignant neoplasm, especially stomach cancer, is rare. We experienced a case of a 60 year-old male patient who had complained of facial and lower leg edema. The laboratory findings were consistent with nephrotic syndrome, and CEA was slightly elevated. Gastroduodenoscopy revealed early gastric cancer, which suggested that the nephrotic syndrome should be associated with neoplasm, an example of membranous glomerulonephritis. Wedge resection of stomach was done with incidental splenectomy and liver biopsy. Following microscopic examination, amyloidosis was found to be involved in the liver and spleen. Bone marrow biopsy did not show any evidence of plasma cell dyscrasia. According to the literature, neoplasm can stimulate the production or precipitation of serum amyloid A like chronic infection and inflammation. But we cannot conclude that stomach neoplasm caused secondary amyloidosis, such as renal cell carcinoma or Hodgkin disease, regarding as the possibility of coincidental amyloidosis. We report a case of amyloidosis associated with early gastric cancer, represented by nephrotic syndrome.