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Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening

DC Field Value Language
dc.contributor.author정다운-
dc.date.accessioned2015-07-15T16:51:36Z-
dc.date.available2015-07-15T16:51:36Z-
dc.date.issued2003-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113740-
dc.description.abstractAn improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.-
dc.description.statementOfResponsibilityopen-
dc.format.extent11804~11805-
dc.relation.isPartOfJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCombinatorial Chemistry Techniques/methods-
dc.subject.MESHDrug Evaluation, Preclinical/methods*-
dc.subject.MESHTriazines/chemistry*-
dc.subject.MESHZebrafish/embryology-
dc.subject.MESHZebrafish/genetics*-
dc.titleFacilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorSonya M. Khersonsky-
dc.contributor.googleauthorDa-Woon Jung-
dc.contributor.googleauthorYoung-Tae Chang-
dc.contributor.googleauthorThomas A. Neubert-
dc.contributor.googleauthorVivekananda Shetty-
dc.contributor.googleauthorEric M. Jacobson-
dc.contributor.googleauthorHakryul Jo-
dc.contributor.googleauthorHo-Sang Moon-
dc.contributor.googleauthorDaniel P. Walsh-
dc.contributor.googleauthorTae-Wook Kang-
dc.identifier.doi10.1021/ja035334d-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03588-
dc.relation.journalcodeJ01769-
dc.identifier.eissn1520-5126-
dc.identifier.pmid14505387-
dc.identifier.urlhttp://pubs.acs.org/doi/abs/10.1021/ja035334d-
dc.subject.keyword14505387-
dc.contributor.alternativeNameJung, Da Woon-
dc.contributor.affiliatedAuthorJung, Da Woon-
dc.rights.accessRightsnot free-
dc.citation.volume125-
dc.citation.number39-
dc.citation.startPage11804-
dc.citation.endPage11805-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.125(39) : 11804-11805, 2003-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
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