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Identification of Epithelial Cell Adhesion Molecule Autoantibody in Patients with Ovarian Cancer
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.date.accessioned | 2015-07-15T16:51:23Z | - |
dc.date.available | 2015-07-15T16:51:23Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113733 | - |
dc.description.abstract | The epithelial cell adhesion molecule (Ep-CAM) exhibited an ovarian cancer:normal human ovarian surface epithelium ratio of 444. For validation studies, real-time quantitative PCR analysis and immunohistochemistry were performed in normal and malignant ovarian epithelial cell lines and tissues. To evaluate the potential of the Ep-CAM autoantibody as a tumor marker, we examined the amount of Ep-CAM autoantibody in serum samples obtained from ovarian cancer patients and normal controls by an ELISA. Real-time quantitative PCR analysis revealed significant overexpression of Ep-CAM mRNA in cancer cell lines (P < 0.001) and microdissected cancer tissues (P < 0.05), compared with that in cultured normal human ovarian surface epithelium and microdissected germinal epithelium, respectively. Immunolocalization of the Ep-CAM autoantibody showed that the sera of ovarian cancer patients expressed higher levels of Ep-CAM autoantibody than benign tumor patients and normal controls (P < 0.05). The levels of Ep-CAM autoantibody found were as follows: 0.132 in 52 patients with ovarian cancer, 0.098 in 26 cases with benign gynecologic disease, and 0.090 in 26 normal women. This investigation has shown that the Ep-CAM autoantibody was found to be associated with ovarian cancer and suggested that future research assessing its clinical usefulness would be worthwhile. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antigens, Neoplasm/immunology* | - |
dc.subject.MESH | Autoantibodies/blood* | - |
dc.subject.MESH | Cell Adhesion Molecules/immunology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Epithelial Cell Adhesion Molecule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Nucleic Acid Hybridization | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Ovarian Neoplasms/blood* | - |
dc.subject.MESH | Ovarian Neoplasms/immunology* | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Ovary/pathology | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.title | Identification of Epithelial Cell Adhesion Molecule Autoantibody in Patients with Ovarian Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Dorothee Herlyn | - |
dc.contributor.googleauthor | Samuel C. Mok | - |
dc.contributor.googleauthor | Ross S. Berkowitz | - |
dc.contributor.googleauthor | Daniel W. Cramer | - |
dc.contributor.googleauthor | Steven J. Skates | - |
dc.contributor.googleauthor | Karen H. Lu | - |
dc.contributor.googleauthor | John O. Schorge | - |
dc.contributor.googleauthor | Dong-Choon Park | - |
dc.contributor.googleauthor | Kwong-kwok Wong | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J00564 | - |
dc.identifier.pmid | 14581349 | - |
dc.subject.keyword | 14581349 | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 4782 | - |
dc.citation.endPage | 4791 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, Vol.9(13) : 4782-4791, 2003 | - |
dc.identifier.rimsid | 49055 | - |
dc.type.rims | ART | - |
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