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국소 뇌허혈에서 뇌저온 요법이 허혈 손상 및 Matrix metalloproteinase 활성도에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 이경열 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2015-07-15T16:49:17Z | - |
dc.date.available | 2015-07-15T16:49:17Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113664 | - |
dc.description.abstract | Background: Effects of hypothermia have been demonstrated in experimental animals with cerebral ischemia. Although the exact mechanisms of hypothermic effects are unknown, decrease of the blood-brain barrier (BBB) permeability, inhibition of free radical generation, and anti-inflammatory actions have been suggested. Matrix metalloproteinases (MMPs) may play a role in the hypothermic effect because they are known to mediate neuro-inflammatory responses and BBB breakdown. M e t h o d s: The rats were subjected to 2 hours of middle cerebral artery occlusion (MCAO) and 18 hours of reperfusion. The normothermia group was maintained at 37℃. Moderate hypothermia was induced by maintaining the temperature at 32℃ during MCAO in the intra-ischemic hypothermia (IH) group, and for 2 hours immediately after reperfusion in the postischemic hypothermia (PH) group. The infarction size in coronal slices were measured after 2,3,5-triphenyltetrazolium chloride stain. By gelatin zymography, the activity of MMP-2 and MMP-9 was measured. Evans blue extravasation methods were used to determine the BBB disruption. Results: The infarction size was significantly decreased in the IH group compared to the normothermia group. The MMP-2 and MMP-9 activities in the ischemic hemispheres was significantly decreased in the IH group compared to the normothermia group. In the PH group, only the MMP-2 activity was significantly decreased compared to the normothermia group. Infarction size was significantly correlated with MMP-2 (r=0.688), and MMP-9 (r=0.707) activities. The disruption of BBB was significantly reduced in the IH group compared to the normothermia group. C o n c l u s I o n s: Intra-ischemic hypothermia effectively attenuated ischemic injury. Hypothermia-mediated inhibition of MMP-2 and MMP-9 activities may contribute to this protective effect. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association (대한신경과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cerebral infarction | - |
dc.subject.MESH | Hypothermia | - |
dc.subject.MESH | Matrix metalloproteinase | - |
dc.subject.MESH | Blood-brain barrier | - |
dc.title | 국소 뇌허혈에서 뇌저온 요법이 허혈 손상 및 Matrix metalloproteinase 활성도에 미치는 영향 | - |
dc.title.alternative | Effect of brain hypothermia on ischemic injury and matrix metalloproteinase activity in focal cerebral ischemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 이경열 | - |
dc.contributor.googleauthor | 김은희 | - |
dc.contributor.googleauthor | 선우일남 | - |
dc.contributor.googleauthor | 이병인 | - |
dc.contributor.googleauthor | 허지회 | - |
dc.contributor.googleauthor | 김경환 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J01836 | - |
dc.subject.keyword | Cerebral infarction | - |
dc.subject.keyword | Hypothermia | - |
dc.subject.keyword | Matrix metalloproteinase | - |
dc.subject.keyword | Blood-brain barrier | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 386 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association (대한신경과학회지), Vol.21(4) : 378-386, 2003 | - |
dc.identifier.rimsid | 44828 | - |
dc.type.rims | ART | - |
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