Cited 17 times in
Effects of phosphodiesterase inhibitors on oesophageal neuromuscular functions
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.date.accessioned | 2015-07-15T16:43:42Z | - |
dc.date.available | 2015-07-15T16:43:42Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1350-1925 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113479 | - |
dc.description.abstract | The cyclic nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) mediate the inhibitory effects of vasoactive intestinal polypeptide and nitric oxide on oesophageal smooth muscle. Phosphodiesterases (PDE) terminate their actions. We hypothesized that PDE inhibitors alter nerve-induced responses of oesophageal and lower oesophageal sphincter (LES) smooth muscle. An electrical field known to activate intrinsic oesophageal nerves was used to stimulate transverse muscle strips from the opossum oesophagus. This produced a contractile off-response from circular oesophageal muscle and a biphasic relaxation of the LES - an initial rapid relaxation (R1) and a slower sustained relaxation (R2). The effects on LES and oesophageal muscle of zaprinast (type V), zardaverine (type III/IV) and theophylline (non-specific) PDE inhibitors were explored. All three PDE inhibitors decreased LES tone and attenuated the off-response. Zaprinast and theophylline increased the latency of the off-response. Zaprinast prolonged R1, and slowed its recovery. It also increased the percentage relaxation of the second R2. Zardaverine increased the percentage relaxation of R2. Theophylline slowed the recovery of R2. PDEs play a role in maintaining LES tone and its recovery after LES relaxation. They may also modulate oesophageal motor activity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 625~633 | - |
dc.relation.isPartOf | NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Electric Stimulation/methods | - |
dc.subject.MESH | Esophagogastric Junction/drug effects | - |
dc.subject.MESH | Esophagogastric Junction/enzymology | - |
dc.subject.MESH | Esophagogastric Junction/innervation | - |
dc.subject.MESH | Esophagus/drug effects* | - |
dc.subject.MESH | Esophagus/enzymology* | - |
dc.subject.MESH | Esophagus/innervation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle Relaxation/drug effects | - |
dc.subject.MESH | Muscle Relaxation/physiology | - |
dc.subject.MESH | Muscle, Smooth/drug effects | - |
dc.subject.MESH | Muscle, Smooth/enzymology | - |
dc.subject.MESH | Opossums | - |
dc.subject.MESH | Phosphodiesterase Inhibitors/pharmacology* | - |
dc.title | Effects of phosphodiesterase inhibitors on oesophageal neuromuscular functions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | H. Park | - |
dc.contributor.googleauthor | E. Clark | - |
dc.contributor.googleauthor | J. L. Conklin | - |
dc.identifier.doi | 10.1046/j.1350-1925.2003.00444.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.relation.journalcode | J02329 | - |
dc.identifier.eissn | 1365-2982 | - |
dc.identifier.pmid | 14651598 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1046/j.1350-1925.2003.00444.x/abstract | - |
dc.subject.keyword | adenosine 3′,5′‐cyclic monophosphate | - |
dc.subject.keyword | enteric nervous system | - |
dc.subject.keyword | guanosine 3′,5′‐cyclic monophosphate | - |
dc.subject.keyword | lower oesophageal sphincter | - |
dc.subject.keyword | oesophagus | - |
dc.subject.keyword | phosphodiesterase | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 625 | - |
dc.citation.endPage | 633 | - |
dc.identifier.bibliographicCitation | NEUROGASTROENTEROLOGY AND MOTILITY, Vol.15(6) : 625-633, 2003 | - |
dc.identifier.rimsid | 49296 | - |
dc.type.rims | ART | - |
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