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Effects of phosphodiesterase inhibitors on oesophageal neuromuscular functions

DC Field Value Language
dc.contributor.author박효진-
dc.date.accessioned2015-07-15T16:43:42Z-
dc.date.available2015-07-15T16:43:42Z-
dc.date.issued2003-
dc.identifier.issn1350-1925-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113479-
dc.description.abstractThe cyclic nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) mediate the inhibitory effects of vasoactive intestinal polypeptide and nitric oxide on oesophageal smooth muscle. Phosphodiesterases (PDE) terminate their actions. We hypothesized that PDE inhibitors alter nerve-induced responses of oesophageal and lower oesophageal sphincter (LES) smooth muscle. An electrical field known to activate intrinsic oesophageal nerves was used to stimulate transverse muscle strips from the opossum oesophagus. This produced a contractile off-response from circular oesophageal muscle and a biphasic relaxation of the LES - an initial rapid relaxation (R1) and a slower sustained relaxation (R2). The effects on LES and oesophageal muscle of zaprinast (type V), zardaverine (type III/IV) and theophylline (non-specific) PDE inhibitors were explored. All three PDE inhibitors decreased LES tone and attenuated the off-response. Zaprinast and theophylline increased the latency of the off-response. Zaprinast prolonged R1, and slowed its recovery. It also increased the percentage relaxation of the second R2. Zardaverine increased the percentage relaxation of R2. Theophylline slowed the recovery of R2. PDEs play a role in maintaining LES tone and its recovery after LES relaxation. They may also modulate oesophageal motor activity.-
dc.description.statementOfResponsibilityopen-
dc.format.extent625~633-
dc.relation.isPartOfNEUROGASTROENTEROLOGY AND MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHElectric Stimulation/methods-
dc.subject.MESHEsophagogastric Junction/drug effects-
dc.subject.MESHEsophagogastric Junction/enzymology-
dc.subject.MESHEsophagogastric Junction/innervation-
dc.subject.MESHEsophagus/drug effects*-
dc.subject.MESHEsophagus/enzymology*-
dc.subject.MESHEsophagus/innervation-
dc.subject.MESHFemale-
dc.subject.MESHIn Vitro Techniques-
dc.subject.MESHMale-
dc.subject.MESHMuscle Relaxation/drug effects-
dc.subject.MESHMuscle Relaxation/physiology-
dc.subject.MESHMuscle, Smooth/drug effects-
dc.subject.MESHMuscle, Smooth/enzymology-
dc.subject.MESHOpossums-
dc.subject.MESHPhosphodiesterase Inhibitors/pharmacology*-
dc.titleEffects of phosphodiesterase inhibitors on oesophageal neuromuscular functions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorH. Park-
dc.contributor.googleauthorE. Clark-
dc.contributor.googleauthorJ. L. Conklin-
dc.identifier.doi10.1046/j.1350-1925.2003.00444.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01774-
dc.relation.journalcodeJ02329-
dc.identifier.eissn1365-2982-
dc.identifier.pmid14651598-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1046/j.1350-1925.2003.00444.x/abstract-
dc.subject.keywordadenosine 3′,5′‐cyclic monophosphate-
dc.subject.keywordenteric nervous system-
dc.subject.keywordguanosine 3′,5′‐cyclic monophosphate-
dc.subject.keywordlower oesophageal sphincter-
dc.subject.keywordoesophagus-
dc.subject.keywordphosphodiesterase-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.rights.accessRightsnot free-
dc.citation.volume15-
dc.citation.number6-
dc.citation.startPage625-
dc.citation.endPage633-
dc.identifier.bibliographicCitationNEUROGASTROENTEROLOGY AND MOTILITY, Vol.15(6) : 625-633, 2003-
dc.identifier.rimsid49296-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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