Cited 11 times in
Estrogen release from metallic stent surface for the prevention of restenosis
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-07-15T16:42:40Z | - |
dc.date.available | 2015-07-15T16:42:40Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113444 | - |
dc.description.abstract | For the prevention of coronary restenosis, estrogen was coupled onto a metallic stent and in vitro release of estrogen was investigated. Estrogen was introduced to the metal surface using a hydrolysable covalent bond for local sustained delivery of drug as follows: (i) the stainless steel (SS) surface was activated with silane by plasma polymerization, (ii) the activated surface (SS–Si surface) was treated with acrylic acid by plasma polymerization (SS–Si–AAc surface), and (iii) 17β-estradiol (E2) was covalently linked to the carboxyl group on that surface (SS–Si–AAc–E2 surface). The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and water contact angle measurement. The amount of E2 was measured by UV–visible spectrophotometry and high performance liquid chromatography (HPLC). The in vitro release profile of E2 demonstrated sustained release of E2 in aqueous buffer. In summary, a novel method of immobilizing estrogen onto a metallic stent surface using plasma polymerization has been developed. The obtained results attest to the usefulness of the estrogen-releasing stent for preventing restenosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 83~91 | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Delayed-Action Preparations/administration & dosage | - |
dc.subject.MESH | Delayed-Action Preparations/pharmacokinetics | - |
dc.subject.MESH | Estrogens/administration & dosage* | - |
dc.subject.MESH | Estrogens/chemistry | - |
dc.subject.MESH | Estrogens/pharmacokinetics | - |
dc.subject.MESH | Graft Occlusion, Vascular/prevention & control* | - |
dc.subject.MESH | Stainless Steel/chemistry | - |
dc.subject.MESH | Stainless Steel/pharmacokinetics* | - |
dc.subject.MESH | Stents*/adverse effects | - |
dc.subject.MESH | Surface Properties/drug effects | - |
dc.title | Estrogen release from metallic stent surface for the prevention of restenosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yoon Ki Joung | - |
dc.contributor.googleauthor | Hyun Il Kim | - |
dc.contributor.googleauthor | Ki Dong Park | - |
dc.contributor.googleauthor | Yang Soo Jang | - |
dc.contributor.googleauthor | Kwang Hoe Chung | - |
dc.contributor.googleauthor | Sung Soo Kim | - |
dc.identifier.doi | 10.1016/S0168-3659(03)00305-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01352 | - |
dc.identifier.eissn | 1873-4995 | - |
dc.identifier.pmid | 14499187 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168365903003055 | - |
dc.subject.keyword | Restenosis | - |
dc.subject.keyword | Estrogen-releasing stent | - |
dc.subject.keyword | Estrogen immobilization | - |
dc.subject.keyword | In vitro release | - |
dc.subject.keyword | Metallic stent | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 92 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 91 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, Vol.92(1-2) : 83-91, 2003 | - |
dc.identifier.rimsid | 49269 | - |
dc.type.rims | ART | - |
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