Cited 33 times in
Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2015-07-15T16:42:17Z | - |
dc.date.available | 2015-07-15T16:42:17Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113431 | - |
dc.description.abstract | BACKGROUND: IL-13 is a central mediator of allergen-induced airway hyperresponsiveness (AHR), but its role in respiratory syncytial virus (RSV)-induced AHR is not defined. The combination of allergen exposure and RSV infection is known to increase AHR and lung inflammation, but whether IL-13 regulates this increase is similarly not known. OBJECTIVE: Our objective was to determine the role of RSV infection and IL-13 on airway responsiveness and lung inflammation on sensitized and challenged mice. METHODS: Using a murine model of RSV infection and allergen exposure, we examined the role of IL-13 in the development of AHR and lung inflammation in IL-13 knockout mice, as well as using a potent IL-13 inhibitor (IL-13i). Mice were sensitized and challenged to allergen, and 6 days after the last challenge, they were infected with RSV. IL-13 was inhibited using an IL-13 receptor alpha(2)-human IgG fusion protein. AHR to inhaled methacholine was measured 6 days after infection, as was bronchoalveolar lavage fluid and lung inflammatory and cytokine responses. RESULTS: RSV-induced AHR was unaffected by the IL-13i, despite prevention of goblet cell hyperplasia. Similar results were seen in IL-13-deficient mice. In sensitized and challenged mice, RSV infection significantly increased AHR, and after IL-13i treatment, AHR was significantly reduced, but to the levels seen in RSV-infected mice alone. CONCLUSIONS: These results indicate that despite some similarities, the mechanisms leading to AHR induced by RSV are different from those that follow allergen sensitization and challenge. Because IL-13 inhibition is effective in preventing the increases in AHR and mucus production in sensitized and challenged mice infected with RSV, IL-13i could play an important role in preventing the consequences of viral infection in patients with allergic asthma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1078~1087 | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Respiratory syncytial virus | - |
dc.subject.MESH | airway hyperresponsiveness | - |
dc.subject.MESH | IL-13 | - |
dc.title | Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung Won Park | - |
dc.contributor.googleauthor | Christian Taube | - |
dc.contributor.googleauthor | Erwin W. Gelfand | - |
dc.contributor.googleauthor | Debra D. Donaldson | - |
dc.contributor.googleauthor | Azzeddine Dakhama | - |
dc.contributor.googleauthor | Nobuaki Miyahara | - |
dc.contributor.googleauthor | Katsuyuki Takeda | - |
dc.contributor.googleauthor | Annette Balhorn | - |
dc.contributor.googleauthor | Anthony Joetham | - |
dc.contributor.googleauthor | Eun Seok Yang | - |
dc.identifier.doi | 10.1016/j.jaci.2003.08.046 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J01228 | - |
dc.identifier.eissn | 1097-6825 | - |
dc.identifier.pmid | 10.1016/j.jaci.2003.08.046 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0091674903022097 | - |
dc.subject.keyword | Respiratory syncytial virus | - |
dc.subject.keyword | airway hyperresponsiveness | - |
dc.subject.keyword | IL-13 | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 112 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1078 | - |
dc.citation.endPage | 1087 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.112(6) : 1078-1087, 2003 | - |
dc.identifier.rimsid | 49258 | - |
dc.type.rims | ART | - |
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