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Optimization of the Erbium : YAG Laser for Precise Ineision of Ureteral and Urethral Tissues : In Vitro and In Vivo Results

DC FieldValueLanguage
dc.contributor.author나군호-
dc.date.accessioned2015-07-15T16:42:10Z-
dc.date.available2015-07-15T16:42:10Z-
dc.date.issued2003-
dc.identifier.issn0196-8092-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113427-
dc.description.abstractBACKGROUND AND OBJECTIVES: Tissue damage during endoscopic treatment of urethral and ureteral strictures may result in stricture recurrence. The Erbium:YAG laser ablates soft tissues with minimal peripheral damage and may be a promising alternative to cold knife and Holmium:YAG laser for precise incision of urological strictures. STUDY DESIGN/MATERIALS AND METHODS: Optimization of the Er:YAG laser was conducted using ex vivo porcine ureteral and canine urethral tissues. Preliminary in vivo studies were also performed in a laparoscopic porcine ureteral model with exposed ureter. Laser radiation with a wavelength of 2.94 microm, pulse lengths of 8, 70, and 220 microseconds, output energies of 2-35 mJ, fluences of 1-25 J/cm2, and pulse repetition rates of 5-30 Hz, was delivered through 250-microm and 425-microm core germanium oxide optical fibers in direct contact with tissue. RESULTS: Ex vivo perforation thresholds measured 2-4 J/cm2, with ablation rates of 50 microm/pulse at fluences of 6-11 J/cm2. In vivo perforation thresholds were approximately 1.8 J/cm2, with the ureter perforated in less than 20 pulses at fluences greater than 3.6 J/cm2. Peripheral thermal damage in tissue decreased from 30 to 60 microm to 10-20 microm as the laser pulse length decreased from 220 to 8 microseconds. Mechanical tissue damage was observed at the 8 microseconds pulse duration. CONCLUSIONS: The Er:YAG laser, operating at a pulse duration of approximately 70 microseconds, a fluence greater than approximately 4 J/cm2, and a repetition rate less than 20 Hz, is capable of rapidly incising urethral and ureteral tissues with minimal thermal and mechanical side-effects.-
dc.description.statementOfResponsibilityopen-
dc.format.extent108~114-
dc.relation.isPartOfLASERS IN SURGERY AND MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHstricture-
dc.subject.MESHurethra-
dc.subject.MESHureter-
dc.subject.MESHErbium-
dc.subject.MESHHolmium-
dc.subject.MESHlaser-
dc.subject.MESHablation-
dc.subject.MESHincision-
dc.titleOptimization of the Erbium : YAG Laser for Precise Ineision of Ureteral and Urethral Tissues : In Vitro and In Vivo Results-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorNathaniel M. Fried-
dc.contributor.googleauthorZelalem Tesfaye-
dc.contributor.googleauthorPooya Hejazi-
dc.contributor.googleauthorKoon H. Rha-
dc.contributor.googleauthorAlbert M. Ong-
dc.identifier.doi10.1002/lsm.10205-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01227-
dc.relation.journalcodeJ02159-
dc.identifier.eissn1096-9101-
dc.identifier.pmid10.1002/lsm.10205-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/lsm.10205/abstract-
dc.subject.keywordstricture-
dc.subject.keywordurethra-
dc.subject.keywordureter-
dc.subject.keywordErbium-
dc.subject.keywordHolmium-
dc.subject.keywordlaser-
dc.subject.keywordablation-
dc.subject.keywordincision-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage108-
dc.citation.endPage114-
dc.identifier.bibliographicCitationLASERS IN SURGERY AND MEDICINE, Vol.33(2) : 108-114, 2003-
dc.identifier.rimsid49256-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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