Cited 39 times in
Transient Neutrophil Infiltration After Allergen Challenge Is Dependent on Specific Antibodies and FcγIII Receptors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2015-07-15T16:41:29Z | - |
dc.date.available | 2015-07-15T16:41:29Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113404 | - |
dc.description.abstract | Following allergen challenge of sensitized mice, neutrophils are the first inflammatory cells found in bronchoalveolar lavage (BAL) fluid. To determine the underlying mechanism for their accumulation, mice were sensitized to OVA on days 0 and 14, and received, on day 28, a single intranasal challenge (s.i.n.) with either OVA or ragweed. Eight hours after the s.i.n., BAL fluid was obtained. BALB/c mice sensitized and challenged with OVA showed significantly higher total cell counts and numbers of neutrophils in BAL fluid compared to the OVA-sensitized and ragweed-challenged or nonsensitized mice. Levels of neutrophil chemokines in BAL fluid supernatants were markedly elevated in the sensitized and OVA-challenged mice; FcεRI-deficient mice showed comparable numbers of neutrophils and neutrophil chemokines in BAL fluid after s.i.n. But in sensitized mice lacking the Fc common γ-chain and B cell-deficient mice, the number of neutrophils and levels of neutrophil chemokines in BAL fluid were significantly lower. Further, mice lacking the FcγRIII did not develop this early neutrophil influx. Neutrophil infiltration could be induced in naive mice following intranasal instillation of allergen combined with allergen-specific IgG1. In addition, macrophages from sensitized mice were stimulated with allergen and activated to produce neutrophil chemokines. These results demonstrate that neutrophil influx after allergen challenge requires prior sensitization, is allergen-specific, is mediated through FcγRIII, and is dependent on the presence of Ab. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4301~4309 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Intranasal | - |
dc.subject.MESH | Agammaglobulinemia/genetics | - |
dc.subject.MESH | Agammaglobulinemia/immunology | - |
dc.subject.MESH | Agammaglobulinemia/pathology | - |
dc.subject.MESH | Allergens/administration & dosage* | - |
dc.subject.MESH | Allergens/immunology* | - |
dc.subject.MESH | Ambrosia/immunology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibody Specificity*/genetics | - |
dc.subject.MESH | B-Lymphocytes/immunology | - |
dc.subject.MESH | B-Lymphocytes/pathology | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/cytology | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/immunology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chemokines/blood | - |
dc.subject.MESH | Chemokines/metabolism | - |
dc.subject.MESH | Epitopes/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunization | - |
dc.subject.MESH | Immunoglobulin E/physiology* | - |
dc.subject.MESH | Immunoglobulin G/metabolism | - |
dc.subject.MESH | Immunoglobulin G/physiology* | - |
dc.subject.MESH | Lymphopenia/genetics | - |
dc.subject.MESH | Lymphopenia/immunology | - |
dc.subject.MESH | Lymphopenia/pathology | - |
dc.subject.MESH | Macrophages, Alveolar/immunology | - |
dc.subject.MESH | Macrophages, Alveolar/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Neutrophil Infiltration/genetics | - |
dc.subject.MESH | Neutrophil Infiltration/immunology* | - |
dc.subject.MESH | Neutrophils/immunology | - |
dc.subject.MESH | Neutrophils/metabolism | - |
dc.subject.MESH | Ovalbumin/administration & dosage | - |
dc.subject.MESH | Ovalbumin/immunology | - |
dc.subject.MESH | Receptors, IgG/deficiency | - |
dc.subject.MESH | Receptors, IgG/genetics | - |
dc.subject.MESH | Receptors, IgG/physiology* | - |
dc.title | Transient Neutrophil Infiltration After Allergen Challenge Is Dependent on Specific Antibodies and FcγIII Receptors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Christian Taube | - |
dc.contributor.googleauthor | Azzeddine Dakhama | - |
dc.contributor.googleauthor | Erwin W. Gelfand | - |
dc.contributor.googleauthor | Jerry A. Nick | - |
dc.contributor.googleauthor | Katie R. Poch | - |
dc.contributor.googleauthor | Toshiyuki Takai | - |
dc.contributor.googleauthor | Annette Balhorn | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Anthony Joetham | - |
dc.contributor.googleauthor | Katsuyuki Takeda | - |
dc.contributor.googleauthor | Yeong-Ho Rha | - |
dc.identifier.doi | 10.4049/jimmunol.170.8.4301 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 12682266 | - |
dc.subject.keyword | 12682266 | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 170 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4301 | - |
dc.citation.endPage | 4309 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.170(8) : 4301-4309, 2003 | - |
dc.identifier.rimsid | 49237 | - |
dc.type.rims | ART | - |
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