Cited 68 times in
Vγ4+ γδ T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2015-07-15T16:41:15Z | - |
dc.date.available | 2015-07-15T16:41:15Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113396 | - |
dc.description.abstract | The Vγ4+ pulmonary subset of γδ T cells regulates innate airway responsiveness in the absence of αβ T cells. We now have examined the same subset in a model of allergic airway disease, OVA-sensitized and challenged mice that exhibit Th2 responses, pulmonary inflammation, and airway hyperreactivity (AHR). In sensitized mice, Vγ4+ cells preferentially increased in number following airway challenge. Depletion of Vγ4+ cells before the challenge substantially increased AHR in these mice, but had no effect on airway responsiveness in normal, nonchallenged mice. Depletion of Vγ1+ cells had no effect on AHR, and depletion of all TCR-δ+ cells was no more effective than depletion of Vγ4+ cells alone. Adoptively transferred pulmonary lymphocytes containing Vγ4+ cells inhibited AHR, but lost this ability when Vγ4+ cells were depleted, indicating that these cells actively suppress AHR. Eosinophilic infiltration of the lung and airways, or goblet cell hyperplasia, was not affected by depletion of Vγ4+ cells, although cytokine-producing αβ T cells in the lung increased. These findings establish Vγ4+ γδ T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3170~3178 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Vγ4+ γδ T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Youn-Soo Hahn | - |
dc.contributor.googleauthor | Christian Taube | - |
dc.contributor.googleauthor | Willi K. Born | - |
dc.contributor.googleauthor | Erwin W. Gelfand | - |
dc.contributor.googleauthor | Rebecca L. O’Brien | - |
dc.contributor.googleauthor | Michael Lahn | - |
dc.contributor.googleauthor | Christina L. Roark | - |
dc.contributor.googleauthor | M. Kemal Aydintug | - |
dc.contributor.googleauthor | J. M. Wands | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Katsuyuki Takeda | - |
dc.contributor.googleauthor | Niyun Jin | - |
dc.identifier.doi | 10.4049/jimmunol.171.6.3170 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 10.4049/jimmunol.171.6.3170 | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 171 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 3170 | - |
dc.citation.endPage | 3178 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.171(6) : 3170-3178, 2003 | - |
dc.identifier.rimsid | 49232 | - |
dc.type.rims | ART | - |
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