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p38 Mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-γ in fetal brain astrocytes

Authors
 J. Lee  ;  J.-S. Shin  ;  I.-H. Choi  ;  S.-J. Kim  ;  S.-J. Choi  ;  D. Kwon  ;  J.Y. Park 
Citation
 JOURNAL OF NEUROSCIENCE RESEARCH, Vol.74(6) : 884-890, 2003 
Journal Title
 JOURNAL OF NEUROSCIENCE RESEARCH 
ISSN
 0360-4012 
Issue Date
2003
MeSH
Apoptosis/genetics* ; Apoptosis Regulatory Proteins ; Astrocytes/cytology* ; Astrocytes/enzymology ; Astrocytes/metabolism* ; Brain/embryology ; Brain/enzymology ; Brain/metabolism* ; Fetus ; Gene Expression Regulation, Developmental* ; Humans ; Interferon-gamma/pharmacology* ; Ligands ; Membrane Glycoproteins/biosynthesis* ; Membrane Glycoproteins/genetics ; Mitogen-Activated Protein Kinases/physiology* ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha/biosynthesis* ; Tumor Necrosis Factor-alpha/genetics ; p38 Mitogen-Activated Protein Kinases
Keywords
astrocytes ; IFN-y ; p38 kinase ; TRAIL
Abstract
This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jnr.10815/abstract
DOI
10.1002/jnr.10815
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113378
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