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Dosimetry in leakage of 188Re-DTPA during intracoronary balloon brachytherapy

Authors
 Jin Chul Paeng  ;  Dong Soo Lee  ;  Myung Chul Lee  ;  Myoung-Mook Lee  ;  In-Ho Chae  ;  Jae Min Jeong  ;  June-Key Chung  ;  Han-Mo Yang  ;  Won Jun Kang 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.30(9) : 1263-1265, 2003 
Journal Title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN
 1619-7070 
Issue Date
2003
MeSH
Angioplasty, Balloon, Coronary ; Body Burden ; Brachytherapy/adverse effects ; Brachytherapy/methods* ; Catheterization/adverse effects ; Catheterization/methods ; Coronary Disease/radiotherapy* ; Coronary Disease/surgery ; Extravasation of Diagnostic and Therapeutic Materials/diagnostic imaging* ; Humans ; Male ; Middle Aged ; Organ Specificity ; Pentetic Acid/adverse effects ; Pentetic Acid/analysis* ; Pentetic Acid/therapeutic use* ; Radiation Injuries/prevention & control ; Radiation Protection/methods* ; Radioisotopes/adverse effects ; Radioisotopes/analysis* ; Radioisotopes/therapeutic use* ; Radiometry/methods* ; Radionuclide Imaging ; Radiopharmaceuticals/adverse effects ; Radiopharmaceuticals/analysis ; Radiopharmaceuticals/therapeutic use ; Rhenium/adverse effects ; Rhenium/analysis* ; Rhenium/therapeutic use* ; Whole-Body Counting/methods*
Keywords
Intracoronary brachytherapy ; 188Re-DTPA Dosimetry
Abstract
Rhenium-188 is reported to be one of the best radionuclides for intracoronary balloon brachytherapy. Among several preparations of 188Re available for brachytherapy, 188Re-diethylene triamine penta-acetic acid (DTPA) and 188Re-mercaptoacetyltriglycine (MAG3) are recommended owing to their rapid excretion via the renal system and the absence of accumulation in the thyroid. The aim of this study was to calculate the dose of radiation exposure in a real human accident. During a 4-year clinical trial of 188Re-DTPA balloon brachytherapy in 242 patients, there was one accident involving balloon leakage. Dosimetry was performed by both image-based and biological analysis. The radiation exposure to the whole body was calculated as 113 mGy by image-based analysis and 83 or 88 mGy by biological analysis, which was approximately half the reported dose in the case of 188Re-perrhenate. The radiation exposures to other vital organs were also within the tolerated ranges. We conclude that 188Re-DTPA has better clinical feasibility and safety for intracoronary balloon brachytherapy than 188Re-perrhenate.
Full Text
http://link.springer.com/article/10.1007%2Fs00259-003-1235-9
DOI
10.1007/s00259-003-1235-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113368
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