Cited 16 times in
Estrogens in female thyroid cancer: Alteration of urinary profiles in pre- and post-operative cases
DC Field | Value | Language |
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dc.contributor.author | 박정수 | - |
dc.contributor.author | 정웅윤 | - |
dc.date.accessioned | 2015-07-15T16:40:07Z | - |
dc.date.available | 2015-07-15T16:40:07Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113358 | - |
dc.description.abstract | To evaluate the potential effect of estrogens in premenopausal female thyroid cancer, the concentrations of 14 estrogens were quantitatively determined in the urine of pre- and post-operative patients with thyroid papillary cancer (18 patients case, 26∼54 years) and normal female subjects (20 cases, 31∼52 years). The highly sensitive gas chromatography–mass spectrometry–selected ion-monitoring method was used for estrogens analysis. And an estrogen-oxidative metabolism and 16α-hydroxyestrone to 2-hydroxyestrone (16α-OH E1/2-OH E1) which is the two primary and competing site of estrogen-oxidation, were determined. Catechol estrogens, including 2-OH E1, were also increased without significant changes of the other estrogen metabolites in pre-operative patients with thyroid papillary cancer compared with normal subjects. The lowest mean value of 16α-OH E1/2-OH E1 was remarked in pre-operative patients, and it was significantly different from the ratio of post-operative cases. As a result, it is suggested that the increase of 2-hydroxylation in estrogen metabolism may have a significant association with female thyroid cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 27~32 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Estrogens/urine* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxyestrones/urine | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Thyroid Neoplasms/surgery | - |
dc.subject.MESH | Thyroid Neoplasms/urine* | - |
dc.title | Estrogens in female thyroid cancer: Alteration of urinary profiles in pre- and post-operative cases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seon Hwa Lee | - |
dc.contributor.googleauthor | Kyung Mee Kim | - |
dc.contributor.googleauthor | Bong Chul Chung | - |
dc.contributor.googleauthor | Cheong Soo Park | - |
dc.contributor.googleauthor | Woung Youn Chung | - |
dc.contributor.googleauthor | Byung Hwa Jung | - |
dc.identifier.doi | 10.1016/S0304-3835(02)00514-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01646 | - |
dc.contributor.localId | A03674 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 12445674 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383502005141 | - |
dc.subject.keyword | Thyroid cancer | - |
dc.subject.keyword | Estrogen profile | - |
dc.subject.keyword | Gas chromatography-mass spectrometry | - |
dc.contributor.alternativeName | Park, Cheong Soo | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Park, Cheong Soo | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 189 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 27 | - |
dc.citation.endPage | 32 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.189(1) : 27-32, 2003 | - |
dc.identifier.rimsid | 55855 | - |
dc.type.rims | ART | - |
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