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N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
DC Field | Value | Language |
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dc.contributor.author | 윤호근 | - |
dc.date.accessioned | 2015-07-15T16:38:29Z | - |
dc.date.available | 2015-07-15T16:38:29Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113304 | - |
dc.description.abstract | The identification and characterization of molecular mechanisms utilized by cells to mediate transcriptional repression at methylated loci are fundamental to understanding the biological consequences of DNA methylation. Here we demonstrate that Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich sequences in a methylation-dependent manner. In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner. Importantly, we demonstrate that Kaiso is required for transcriptional repression of the methylated MTA2 locus. Furthermore, this repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus. Thus, our data demonstrate a critical role for a methyl CpG binding protein in mediating DNA methylation-dependent repression and reveal the mechanism by which it represses transcription. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MOLECULAR CELL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carrier Proteins/genetics | - |
dc.subject.MESH | Carrier Proteins/metabolism | - |
dc.subject.MESH | CpG Islands/genetics* | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | DNA-Binding Proteins/genetics | - |
dc.subject.MESH | DNA-Binding Proteins/metabolism* | - |
dc.subject.MESH | DNA-Cytosine Methylases/genetics | - |
dc.subject.MESH | DNA-Cytosine Methylases/metabolism | - |
dc.subject.MESH | Eukaryotic Cells/metabolism | - |
dc.subject.MESH | Genes, Regulator/genetics* | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Histone Deacetylases/genetics | - |
dc.subject.MESH | Histone Deacetylases/metabolism | - |
dc.subject.MESH | Histones/genetics | - |
dc.subject.MESH | Histones/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lysine/genetics | - |
dc.subject.MESH | Lysine/metabolism | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Nuclear Proteins/metabolism* | - |
dc.subject.MESH | Nuclear Receptor Co-Repressor 1 | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics | - |
dc.subject.MESH | Repressor Proteins/genetics | - |
dc.subject.MESH | Repressor Proteins/metabolism* | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.title | N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Doug W. Chan | - |
dc.contributor.googleauthor | Jiemin Wong | - |
dc.contributor.googleauthor | Jun Qin | - |
dc.contributor.googleauthor | Albert B. Reynolds | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02625 | - |
dc.relation.journalcode | J02256 | - |
dc.identifier.eissn | 1097-4164 | - |
dc.identifier.pmid | 14527417 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1097276503003174 | - |
dc.subject.keyword | 14527417 | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 723 | - |
dc.citation.endPage | 734 | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, Vol.12(3) : 723-734, 2003 | - |
dc.identifier.rimsid | 55818 | - |
dc.type.rims | ART | - |
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