Cited 45 times in
Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-07-15T16:35:27Z | - |
dc.date.available | 2015-07-15T16:35:27Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0022-2275 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113203 | - |
dc.description.abstract | Visceral fat has been associated with multiple cardiovascular disease (CVD) risk factors. The aim of this study was to identify anthropometrical measures most closely associated with some well-known CVD risk factors. Because most Asians at risk have normal body mass index (BMI) according to Western standards, we studied healthy nonobese Korean males (n = 102; age: 36.5 +/- 0.8 years, BMI: 23.8 +/- 0.2 kg/m2). Visceral fat area (VFA) at the fourth lumbar vertebra was associated with increased postprandial triglyceride (TG) response (r = 0.53, P < 0.001) and with plasma malondialdehyde (MDA) (r = 0.36, P < 0.01) and PGF2alpha (r = 0.24, P < 0.05). When matched for BMI and age, men with high VFA (HVFA) (>/=100 cm2; n = 27) had higher blood pressure (P < 0.01), increased consumption of cigarettes (P < 0.01), and lower ratio of energy expenditure to calorie intake (P < 0.01) as compared with low VFA men (<100 cm2; n = 27). Men with HVFA showed higher TG, glucose, and insulin responses following fat and oral glucose tolerance tests respectively higher plasma concentrations of MDA (P < 0.001), urinary PGF2alpha (P < 0.05), and lymphocytes deoxyribonucleic acid tail moments (P < 0.01). Conversely, HVFA was associated with lower testosterone, insulin-like growth factor-1, and brachial artery flow-mediated dilation (P < 0.001). In conclusion, our data indicate that visceral fat accumulation, even in nonobese men, is a major factor contributing to increased CVD risk. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2356~2364 | - |
dc.relation.isPartOf | JOURNAL OF LIPID RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/metabolism* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cardiovascular Diseases/etiology | - |
dc.subject.MESH | Cardiovascular Diseases/metabolism | - |
dc.subject.MESH | DNADamage* | - |
dc.subject.MESH | Endothelium/physiopathology* | - |
dc.subject.MESH | Energy Metabolism | - |
dc.subject.MESH | Fatty Acids, Nonesterified/blood | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin/blood | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | LipidPeroxidation* | - |
dc.subject.MESH | Lipids/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/physiopathology | - |
dc.subject.MESH | PostprandialPeriod/physiology* | - |
dc.subject.MESH | Smoking/adverse effects | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.subject.MESH | Viscera/metabolism* | - |
dc.title | Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Jose M. Ordovas | - |
dc.contributor.googleauthor | Sang Hoon Song | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Ha Jung Ryu | - |
dc.identifier.doi | 10.1194/jlr.M300233-JLR200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01563 | - |
dc.identifier.eissn | 1539-7262 | - |
dc.identifier.pmid | 12951360 | - |
dc.subject.keyword | 12951360 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2356 | - |
dc.citation.endPage | 2364 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LIPID RESEARCH, Vol.44(12) : 2356-2364, 2003 | - |
dc.identifier.rimsid | 54204 | - |
dc.type.rims | ART | - |
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