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CMV 질환의 면역치료법 개발에 대한 최신지견
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임종백 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-07-14T17:32:53Z | - |
dc.date.available | 2015-07-14T17:32:53Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1225-1607 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113108 | - |
dc.description.abstract | Cytomegalovirus (CMV) reactivation in immunocompromised patients such as those undergoing hematopoietic stem cell transplantation (HSCT) and those with HIV infections can cause severe morbidity and mortality despite treatment with appropriate anti-viral agents. The recovery of CMV specific cytotoxic T lymphocytes (CTLs) plays an important role in the reconstitution of CMV specific immunity in immunocompromised patients. Recent studies have reported that CMV reactivation could be successfully treated by adoptive transfer of CMV specific T cell clones from CMV seropositive donors expanded in uitro with CMV infected fibroblasts or lysates of CMV infected cells. Other studies have used immune dominant CMV proteins or peptides to expand CMV-specific cytotoxic T lymphocytes. This review contains clinical manifestation of CMV disease in immunocompromised patients, recent advances of antiviral therapy for CMV disease, the principle of induction of cellular immune response to CMV and clinical application of CMV immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 47~55 | - |
dc.relation.isPartOf | Konkuk Journal of Medical Sciences (건국의과학학술지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | CMV 질환의 면역치료법 개발에 대한 최신지견 | - |
dc.title.alternative | A recent approach of adoptive immunotherapy for cytomegalovirus (CMV) disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 임종백 | - |
dc.contributor.googleauthor | 최종락 | - |
dc.contributor.googleauthor | 이창훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03403 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J01946 | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Lim, Jong Baeck | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | not available | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 55 | - |
dc.identifier.bibliographicCitation | Konkuk Journal of Medical Sciences (건국의과학학술지), Vol.13(2) : 47-55, 2004 | - |
dc.identifier.rimsid | 56819 | - |
dc.type.rims | ART | - |
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