Cited 547 times in
Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형표 | - |
dc.date.accessioned | 2015-07-14T17:28:12Z | - |
dc.date.available | 2015-07-14T17:28:12Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112946 | - |
dc.description.abstract | IL-21 is a type I cytokine whose receptor is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Using IL-21-transgenic mice and hydrodynamics-based gene delivery of IL-21 plasmid DNA into wild-type mice as well as in vitro studies, we demonstrate that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells. Thus, IL-21 differentially influences B cell fate depending on the signaling context, explaining how IL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo. Moreover, we demonstrate that IL-21 unexpectedly induces expression of both Blimp-1 and Bcl-6, indicating mechanisms as to how IL-21 can serve as a complex regulator of B cell maturation and terminal differentiation. Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 5361~5371 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/genetics | - |
dc.subject.MESH | Apoptosis/immunology | - |
dc.subject.MESH | B-Lymphocyte Subsets/cytology* | - |
dc.subject.MESH | B-Lymphocyte Subsets/immunology* | - |
dc.subject.MESH | B-Lymphocyte Subsets/metabolism | - |
dc.subject.MESH | CellDivision/genetics | - |
dc.subject.MESH | CellDivision/immunology | - |
dc.subject.MESH | CellSeparation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | DNA-Binding Proteins/antagonists & inhibitors | - |
dc.subject.MESH | DNA-Binding Proteins/biosynthesis* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin Class Switching/genetics | - |
dc.subject.MESH | Interleukins/biosynthesis | - |
dc.subject.MESH | Interleukins/genetics | - |
dc.subject.MESH | Interleukins/physiology* | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/genetics | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/immunology | - |
dc.subject.MESH | Lymphocyte Count | - |
dc.subject.MESH | Membrane Glycoproteins/biosynthesis | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Mice, Mutant Strains | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | PAX5 Transcription Factor | - |
dc.subject.MESH | PlasmaCells/cytology* | - |
dc.subject.MESH | PlasmaCells/immunology* | - |
dc.subject.MESH | PlasmaCells/metabolism | - |
dc.subject.MESH | Positive Regulatory Domain I-Binding Factor 1 | - |
dc.subject.MESH | Proteoglycans/biosynthesis | - |
dc.subject.MESH | Proto-Oncogene Proteins/biosynthesis* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-6 | - |
dc.subject.MESH | Repressor Proteins/biosynthesis* | - |
dc.subject.MESH | Spleen/anatomy & histology | - |
dc.subject.MESH | Spleen/cytology | - |
dc.subject.MESH | Spleen/immunology | - |
dc.subject.MESH | Syndecans | - |
dc.subject.MESH | Transcription Factors/antagonists & inhibitors | - |
dc.subject.MESH | Transcription Factors/biosynthesis* | - |
dc.subject.MESH | Up-Regulation/immunology | - |
dc.title | Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Katsutoshi Ozaki | - |
dc.contributor.googleauthor | Rosanne Spolski | - |
dc.contributor.googleauthor | Warren J. Leonard | - |
dc.contributor.googleauthor | Peter E. Lipsky | - |
dc.contributor.googleauthor | Herbert C. Morse | - |
dc.contributor.googleauthor | Derry C. Roopenian | - |
dc.contributor.googleauthor | Shreeram Akilesh | - |
dc.contributor.googleauthor | Daniel J. Shaffer | - |
dc.contributor.googleauthor | Patrick Hwu | - |
dc.contributor.googleauthor | Chen-Feng Qi | - |
dc.contributor.googleauthor | Gang Wang | - |
dc.contributor.googleauthor | Hyoung-Pyo Kim | - |
dc.contributor.googleauthor | Rachel Ettinger | - |
dc.identifier.doi | 10.4049/jimmunol.173.9.5361 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01163 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 15494482 | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 173 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 5361 | - |
dc.citation.endPage | 5371 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.173(9) : 5361-5371, 2004 | - |
dc.identifier.rimsid | 36814 | - |
dc.type.rims | ART | - |
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