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Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

DC Field Value Language
dc.contributor.author김형표-
dc.date.accessioned2015-07-14T17:28:12Z-
dc.date.available2015-07-14T17:28:12Z-
dc.date.issued2004-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112946-
dc.description.abstractIL-21 is a type I cytokine whose receptor is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Using IL-21-transgenic mice and hydrodynamics-based gene delivery of IL-21 plasmid DNA into wild-type mice as well as in vitro studies, we demonstrate that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells. Thus, IL-21 differentially influences B cell fate depending on the signaling context, explaining how IL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo. Moreover, we demonstrate that IL-21 unexpectedly induces expression of both Blimp-1 and Bcl-6, indicating mechanisms as to how IL-21 can serve as a complex regulator of B cell maturation and terminal differentiation. Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5361~5371-
dc.relation.isPartOfJOURNAL OF IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/genetics-
dc.subject.MESHApoptosis/immunology-
dc.subject.MESHB-Lymphocyte Subsets/cytology*-
dc.subject.MESHB-Lymphocyte Subsets/immunology*-
dc.subject.MESHB-Lymphocyte Subsets/metabolism-
dc.subject.MESHCellDivision/genetics-
dc.subject.MESHCellDivision/immunology-
dc.subject.MESHCellSeparation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDNA-Binding Proteins/antagonists & inhibitors-
dc.subject.MESHDNA-Binding Proteins/biosynthesis*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin Class Switching/genetics-
dc.subject.MESHInterleukins/biosynthesis-
dc.subject.MESHInterleukins/genetics-
dc.subject.MESHInterleukins/physiology*-
dc.subject.MESHLupus Erythematosus, Systemic/genetics-
dc.subject.MESHLupus Erythematosus, Systemic/immunology-
dc.subject.MESHLymphocyte Count-
dc.subject.MESHMembrane Glycoproteins/biosynthesis-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMice, Mutant Strains-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHPAX5 Transcription Factor-
dc.subject.MESHPlasmaCells/cytology*-
dc.subject.MESHPlasmaCells/immunology*-
dc.subject.MESHPlasmaCells/metabolism-
dc.subject.MESHPositive Regulatory Domain I-Binding Factor 1-
dc.subject.MESHProteoglycans/biosynthesis-
dc.subject.MESHProto-Oncogene Proteins/biosynthesis*-
dc.subject.MESHProto-Oncogene Proteins c-bcl-6-
dc.subject.MESHRepressor Proteins/biosynthesis*-
dc.subject.MESHSpleen/anatomy & histology-
dc.subject.MESHSpleen/cytology-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHSyndecans-
dc.subject.MESHTranscription Factors/antagonists & inhibitors-
dc.subject.MESHTranscription Factors/biosynthesis*-
dc.subject.MESHUp-Regulation/immunology-
dc.titleRegulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Environmental Medical Biology (환경의생물학)-
dc.contributor.googleauthorKatsutoshi Ozaki-
dc.contributor.googleauthorRosanne Spolski-
dc.contributor.googleauthorWarren J. Leonard-
dc.contributor.googleauthorPeter E. Lipsky-
dc.contributor.googleauthorHerbert C. Morse-
dc.contributor.googleauthorDerry C. Roopenian-
dc.contributor.googleauthorShreeram Akilesh-
dc.contributor.googleauthorDaniel J. Shaffer-
dc.contributor.googleauthorPatrick Hwu-
dc.contributor.googleauthorChen-Feng Qi-
dc.contributor.googleauthorGang Wang-
dc.contributor.googleauthorHyoung-Pyo Kim-
dc.contributor.googleauthorRachel Ettinger-
dc.identifier.doi10.4049/jimmunol.173.9.5361-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01163-
dc.relation.journalcodeJ01450-
dc.identifier.eissn1550-6606-
dc.identifier.pmid15494482-
dc.contributor.alternativeNameKim, Hyoung Pyo-
dc.contributor.affiliatedAuthorKim, Hyoung Pyo-
dc.rights.accessRightsfree-
dc.citation.volume173-
dc.citation.number9-
dc.citation.startPage5361-
dc.citation.endPage5371-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY, Vol.173(9) : 5361-5371, 2004-
dc.identifier.rimsid36814-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers

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