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Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix - A Potential Predictor of Poor Survival

DC FieldValueLanguage
dc.contributor.author박찬규-
dc.contributor.author서창옥-
dc.contributor.author이종두-
dc.contributor.author정현철-
dc.contributor.author조남훈-
dc.contributor.author표홍렬-
dc.contributor.author금웅섭-
dc.contributor.author김귀언-
dc.contributor.author김용배-
dc.date.accessioned2015-07-14T17:27:05Z-
dc.date.available2015-07-14T17:27:05Z-
dc.date.issued2004-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112908-
dc.description.abstractPURPOSE: To evaluate the potential of the new prognostic information gained by analyzing the coexpression of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in cervical cancer patients. EXPERIMENTAL DESIGN: Sixty-eight patients with International Federation of Gynecology and Obstetrics stage IIB squamous cell carcinoma of the uterine cervix, who underwent concurrent chemoradiotherapy between 1993 and 1996, were divided into the following four groups according to their immunoreactivities for EGFR and COX-2 in paraffin-embedded sections: (a). the EGFR-negative/COX-2-negative group (n = 11); (b). the EGFR-negative/COX-2-positive group (n = 8); (c). the EGFR-positive/COX-2-negative group (n = 27); and (d). the EGFR-positive/COX-2-positive group (n = 22). The clinical features, patterns of treatment failure, and survival data in the four groups were compared. RESULTS: Positive immunoreactivity for EGFR and COX-2 was observed in 49 of 68 (72%) and 19 of 68 (28%), respectively. However, no strong correlation was found between the levels of EGFR and COX-2 immunopositivity (R(2) = 0.05, P = 0.07). Patients in the EGFR-positive/COX-2-positive group had a higher likelihood of locoregional recurrence than those in the other three groups (P = 0.02). Of the patients in the four groups, patients positive for both oncoproteins were found to have the worst prognosis with an overall 5-year disease-free survival rate of 55% compared with 91% for the EGFR-negative/COX-2-negative patients, 88% for the EGFR-negative/COX-2-positive patients, and 69% for the EGFR-positive/COX-2-negative patients (P = 0.05, log-rank test). In addition, the synchronous coexpression of the EGFR and COX-2 oncoproteins was found to be an independent prognostic factor by univariate and multivariate analyses (relative risk = 4.0, P = 0.03). CONCLUSIONS: Given these observations, we conclude that the coexpression of EGFR and COX-2 immunoreactivity may be used as a potent molecular risk factor for predicting the poor survival of patients with the International Federation of Gynecology and Obstetrics stage IIB squamous cell carcinoma of the uterine cervix.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell/enzymology*-
dc.subject.MESHCarcinoma, Squamous Cell/mortality*-
dc.subject.MESHCyclooxygenase 2-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHErbB Receptors/biosynthesis*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIsoenzymes/biosynthesis*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMembrane Proteins-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPrognosis-
dc.subject.MESHProstaglandin-Endoperoxide Synthases/biosynthesis*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUterine Cervical Neoplasms/enzymology*-
dc.subject.MESHUterine Cervical Neoplasms/mortality*-
dc.titleSynchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix - A Potential Predictor of Poor Survival-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorGwi Eon Kim-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorChang Ok Suh-
dc.contributor.googleauthorMison Chun-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorTchan Kyu Park-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorHong Ryull Pyo-
dc.contributor.googleauthorHyun-Cheol Chung-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi0.1158/1078-0432.CCR-0497-03-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01707-
dc.contributor.localIdA01919-
dc.contributor.localIdA03138-
dc.contributor.localIdA03773-
dc.contributor.localIdA03812-
dc.contributor.localIdA04245-
dc.contributor.localIdA00273-
dc.contributor.localIdA00321-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ00564-
dc.identifier.pmid14977838-
dc.contributor.alternativeNamePark, Chan Gyu-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNamePyo, Hong Ryull-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthorPark, Chan Gyu-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorPyo, Hong Ryull-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage1366-
dc.citation.endPage1374-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.10(4) : 1366-1374, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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