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Cigarette Smoking, Alcohol Drinking, Hepatitis B, and Risk for Hepatocellular Carcinoma in Korea

DC Field Value Language
dc.contributor.author지선하-
dc.date.accessioned2015-07-14T17:26:37Z-
dc.date.available2015-07-14T17:26:37Z-
dc.date.issued2004-
dc.identifier.issn0027-8874-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112892-
dc.description.abstractBACKGROUND: Liver cancer is one of the most common cancers worldwide, particularly in Asia and Africa, where infectious hepatitis and aflatoxin exposures are common. We conducted a prospective cohort study of liver cancer in Korea to assess the independent effects and interactions of smoking, alcohol consumption, and hepatitis B on risk of mortality from hepatocellular carcinoma. METHODS: From a total of 1,283,112 men and women free of cancer at baseline, 3807 died from liver cancer during follow-up from 1993 to 2002. All participants reported their smoking and alcohol consumption, and hepatitis B surface antigen (HBsAg) status was documented for 47.2% of the participants. Relative risk and 95% confidence intervals (CIs) of mortality from hepatocellular carcinoma were calculated using proportional hazards models adjusted for age, alcohol drinking, diabetes, and HBsAg status. RESULTS: Current smoking was associated with increased risk of mortality from hepatocellular carcinoma in men (RR = 1.4; 95% CI = 1.3 to 1.6) but not women (RR = 1.1; CI = 0.8 to 1.7). The relative risk of mortality from hepatocellular carcinoma for male HBsAg carriers was 24.3 (95% CI = 21.9 to 26.9) times that in HBsAg-negative males; the relative risk for HBsAg-positive women was 54.4 (95% CI = 24.8 to 119.5). Heavy alcohol drinking was associated with hepatocellular carcinoma mortality risk in the subgroup of men who were tested for HBsAg (RR =1.5; 95% CI = 1.2 to 2.0). There was no interaction among smoking, alcohol drinking, and HBsAg in terms of hepatocellular carcinoma mortality. CONCLUSION: Cigarette smoking, heavy alcohol consumption, and HBsAg were independently associated with increased risk of mortality from hepatocellular carcinoma but did not interact synergistically. The relatively higher increase in mortality from hepatocellular carcinoma in HBsAg-seropositive women compared with men merits further research. PMID: 15601641 [PubMed - indexed for MEDLINE] Free full text-
dc.description.statementOfResponsibilityopen-
dc.format.extent1851~1856-
dc.relation.isPartOfJNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlcohol Drinking/adverse effects-
dc.subject.MESHAlcohol Drinking/epidemiology*-
dc.subject.MESHCarcinoma, Hepatocellular/epidemiology*-
dc.subject.MESHCarcinoma, Hepatocellular/etiology*-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHCohort Studies-
dc.subject.MESHConfounding Factors (Epidemiology)-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B/complications-
dc.subject.MESHHepatitis B/epidemiology*-
dc.subject.MESHHepatitis B Surface Antigens/blood-
dc.subject.MESHHumans-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHLiver Neoplasms/epidemiology*-
dc.subject.MESHLiver Neoplasms/etiology*-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHMale-
dc.subject.MESHMedical Record Linkage-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking/adverse effects-
dc.subject.MESHSmoking/epidemiology*-
dc.titleCigarette Smoking, Alcohol Drinking, Hepatitis B, and Risk for Hepatocellular Carcinoma in Korea-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorHeechoul Ohrr-
dc.contributor.googleauthorJonathan M. Samet-
dc.contributor.googleauthorJae Woong Sull-
dc.identifier.doi10.1093/jnci/djh334-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ01896-
dc.identifier.eissn1460-2105-
dc.identifier.pmid15601641-
dc.subject.keywordsmoking-
dc.subject.keyworddiabetes mellitus-
dc.subject.keywordcancer-
dc.subject.keywordhepatitis b-
dc.subject.keywordalcohol drinking-
dc.subject.keywordcarcinoma-
dc.subject.keywordhepatocellular-
dc.subject.keywordfollow-up-
dc.subject.keywordhepatitis b surface antigens-
dc.subject.keywordkorea-
dc.subject.keywordprospective studies-
dc.subject.keywordmortality-
dc.subject.keywordliver cancer-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsfree-
dc.citation.volume96-
dc.citation.number24-
dc.citation.startPage1851-
dc.citation.endPage1856-
dc.identifier.bibliographicCitationJNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol.96(24) : 1851-1856, 2004-
dc.identifier.rimsid36778-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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