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Cloning of TLR3 Isoform

 Eun Jeong Yang  ;  Jeon Soo Shin  ;  In Hong Choi  ;  Se Jong Kim  ;  Myoung Hee Kim  ;  Hyoung Woo Park  ;  Hyemi Kim 
 Yonsei Medical Journal, Vol.45(2) : 359-361, 2004 
Journal Title
 Yonsei Medical Journal 
Issue Date
Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2, 520 bp cDNAs compared to the 2, 712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Kim, Se Jong(김세종)
Kim, Hye Mi(김혜미)
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Yang, Eun Jeoung(양은정)
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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