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Cloning of TLR3 Isoform

Authors
 Eun Jeong Yang  ;  Jeon Soo Shin  ;  In Hong Choi  ;  Se Jong Kim  ;  Myoung Hee Kim  ;  Hyoung Woo Park  ;  Hyemi Kim 
Citation
 Yonsei Medical Journal, Vol.45(2) : 359-361, 2004 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2004
Abstract
Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2, 520 bp cDNAs compared to the 2, 712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
Yonsei Authors
김명희(Kim, Myoung Hee) ORCID logo https://orcid.org/0000-0001-5652-1452
김세종(Kim, Se Jong)
김혜미(Kim, Hye Mi)
박형우(Park, Hyoung Woo)
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
양은정(Yang, Eun Jeoung)
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112829
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