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Development of DNA microarray for pathogen detection

Authors
 Seung Min Yoo  ;  Ki Chang Keum  ;  Sang Yup Lee  ;  Duke Lee  ;  June Myung Kim  ;  Won Min Yoo  ;  Nae Choon Yoo  ;  Kyung Hee Chang  ;  Jun Yong Choi  ;  So Young Yoo 
Citation
 BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, Vol.9(2) : 93-99, 2004 
Journal Title
 BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 
ISSN
 1226-8372 
Issue Date
2004
Keywords
microarray ; pathogen ; target gene ; probe
Abstract
Pathogens pose a significant threat to humans, animals, and plants. Consequently, a considerable effort has been devoted to developing rapid, convenient, and accurate assays for the detection of these unfavorable organisms. Recently, DNA-microarray based technology is receiving much attention as a powerful tool for pathogen detection. After the target gene is first selected for the unique identification of microorganisms, species-specific probes are designed through bioinformatic analysis of the sequences, which uses the information present in the databases. DNA samples, which were obtained from reference and/or clinical isolates, are properly processed and hybridized with species-specific probes that are immobilized on the surface of the microarray for fluorescent detection. In this study, we review the methods and strategies for the development of DNA microarray for pathogen detection, with the focus on probe design.
Files in This Item:
T200401723.pdf Download
DOI
10.1007/BF02932990
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, June Myung(김준명)
Yoo, Nae Choon(유내춘)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112780
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