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Trinitrobenzene Sulfonic Acid로 유도한 대장염에서 대장통과시간 변화 및 장벽내 Nitric Oxide Synthase의 분포

Other Titles
 Altered Colonic Transit in TNBS-induced Experimental Colitis in Guinea Pig and Distribution of Nitric Oxide Synthase in the Colonic Wall 
 조승현  ;  박효진  ;  이상인  ;  노태웅  ;  지상원  ;  이영호  ;  정준표 
 Korean Journal of Gastroenterology, Vol.44(6) : 308-313, 2004 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Colonic transit ; Colitis ; Nitric oxide synthase ; Trinitrobenzene sulfonic acid
Background/Aims: Inflammation-induced alterations in smooth muscle contractility may be due to the effects on smooth muscle itself, neurotransmitters or enteric nerves. In dextran sulfate sodium-induced colitic rat, the delay in colonic transit was caused by decreased activity and production of neuronal nitric oxide synthase (nNOS) in
the myenteric plexus of the distal colon. The aim of this study was to investigate the relationship between the delay in colonic transit and the distribution of inducible NOS (iNOS) and nNOS immunoreactive cells in the myenteric plexus of trinitrobenzene sulfonic acid (TNBS)-induced colitic guinea pig.

Methods: Sacrificed and their colonic tissues of forty-five TNBS-induced colitic guinea pigs were used to measure the colonic transit, and
analyzed by immunohistochemistry.

Results: Colonic transit was delayed significantly at 3, 7 and 14 days after
administration of TNBS. In control, nNOS immunoreactivity was present in the mucosa, submucosa, lamina propria, and ganglion cells of the myenteric plexus, while after TNBS treatment, reduced nNOS cells were found. However, the number of nNOS ganglion cells in the myenteric plexus was similar to those seen in controls. After administration of TNBS, iNOS immunoreactivity was increased in the mucosa and submucosa, but the number of iNOS positive ganglion cells in the myenteric plexus was not changed compared to control.

Conclusions: It is suggested that in TNBS-induced guinea pig colitis, delayed colonic transit is not associated with the expression of nNOS nor iNOS in the myenteric plexus.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Chung, Jun Pyo(정준표)
Ji, Sang Won(지상원)
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