Cited 1 times in
Proper Cut-off Value of Free to Total PSA Ratio for Detection of Prostate Cancer in Korean Men
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-07-14T17:15:45Z | - |
dc.date.available | 2015-07-14T17:15:45Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112531 | - |
dc.description.abstract | To assess whether the free-to-total prostate specific antigen (PSA) ratio (F/T PSA ratio) would enhance prostate cancer detection in Korean men with serum total PSA levels between 4 and 20 ng/ml. Methods: A total of 240 consecutive patients whose serum PSA levels were between 4 and 20 ng/ml were enrolled in this two-year study. All patients underwent ultrasound-guided transrectal biopsies of the prostate gland. The F/T PSA ratio was measured using the Roche immunoassay. Results: Of the 240 patients, 202 (84%) had benign histologies, while 38 (16%) had prostate cancer. The two patient groups were well matched for age. The mean F/T PSA ratio showed a statistically significant difference between the two groups: in the benign histology group it was 0.14 (0.04 - 0.37), and 0.10 (0.08 - 0.20) in the prostate cancer group (p < 0.05). Out of the 183 patients with a PSA level between 4-10 ng/ml, the mean F/T PSA ratios were 0.14 and 0.11 in the benign histology (n=158) and prostate cancer groups (n=25), respectively (p < 0.05). From the 57 patients with a PSA level between 10 - 20 ng/ml, the mean F/T PSA ratios were 0.14 and 0.10 in the benign histology (n=44) and prostate cancer groups (n=13), respectively (p < 0.05). Overall, when the cut-off value of the F/T PSA ratio was 0.10, the sensitivity and specificity were 75.0% and 76.5%, while for the cut-off value of 0.15 they were 83.3% and 39.7% respectively. Conclusion: Our data demonstrated the usefulness of the free to total PSA ratio in distinguishing benign prostate disease and cancer disease, hence eliminating unnecessary biopsies. It is recommended that a cut-off value for the F/T PSA ratio of 0.10 be applied to Korean men which this is lower than the value used in Western countries. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 873~878 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prostate/pathology | - |
dc.subject.MESH | Prostate-Specific Antigen/blood* | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | ROC Curve | - |
dc.title | Proper Cut-off Value of Free to Total PSA Ratio for Detection of Prostate Cancer in Korean Men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Young Jae Im | - |
dc.contributor.googleauthor | Jae Wook Kim | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.identifier.doi | 10.3349/ymj.2004.45.5.873 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 15515198 | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | biopsy | - |
dc.subject.keyword | free PSA | - |
dc.subject.keyword | Korea | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 873 | - |
dc.citation.endPage | 878 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.45(5) : 873-878, 2004 | - |
dc.identifier.rimsid | 57729 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.