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Effects of tegaserod on ileal peristalsis of guinea pig in vitro

DC FieldValueLanguage
dc.contributor.author박효진-
dc.contributor.author이상인-
dc.contributor.author이영호-
dc.contributor.author정준표-
dc.contributor.author지상원-
dc.date.accessioned2015-07-14T17:14:24Z-
dc.date.available2015-07-14T17:14:24Z-
dc.date.issued2004-
dc.identifier.issn1347-8613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112484-
dc.description.abstractThe mechanisms of prokinetic action of tegaserod in the gastrointestinal tract has not been studied in detail. The aim of this study was to investigate the effect of tegaserod on peristaltic reflexes and propagating peristaltic waves in guinea pig ileum. A partitioned organ bath divided into three chambers was used to investigate the effect of tegaserod on peristaltic reflexes. A sensory stimulus was applied to the intermediate chamber, and changes in the circular muscle tension were monitored in a peripheral chamber. Another peristaltic bath was used to investigate the effect of tegaserod on peristaltic waves induced by intraluminal perfusion. Guinea pig ileum exhibited contractions in the circular muscle both orally and anally in response to mucosal stroking. Tegaserod (10(-8) - 10(-6) M) did not influence the maximal amplitude and the area under the curve of contraction both orally and anally to a mucosal stimulus. Intraluminal perfusion of fluid containing tegaserod (10(-8) - 10(-6) M) significantly increased the number of peristaltic waves in a concentration-dependent manner (P<0.05). Also, tegaserod (10(-8) - 10(-6) M) significantly increased the area under the curve of peristaltic waves (P<0.05). It is concluded that tegaserod has prokinetic action on guinea pig ileum by increasing the number of the circular muscle contractions during peristalsis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent144~152-
dc.relation.isPartOfJOURNAL OF PHARMACOLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHGastrointestinal Agents/pharmacology*-
dc.subject.MESHGuinea Pigs-
dc.subject.MESHIleum/drug effects*-
dc.subject.MESHIleum/physiology-
dc.subject.MESHIn Vitro Techniques-
dc.subject.MESHIndoles/pharmacology*-
dc.subject.MESHIntestinal Mucosa/drug effects-
dc.subject.MESHIntestinal Mucosa/physiology-
dc.subject.MESHMale-
dc.subject.MESHPerfusion/instrumentation-
dc.subject.MESHPerfusion/methods-
dc.subject.MESHPeristalsis/drug effects*-
dc.subject.MESHPeristalsis/physiology-
dc.titleEffects of tegaserod on ileal peristalsis of guinea pig in vitro-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSang Won Ji-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorYoung Ho Lee-
dc.contributor.googleauthorSang In Lee-
dc.contributor.googleauthorJun Pyo Chung-
dc.identifier.doi10.1254/jphs.94.144-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01701-
dc.identifier.eissn1347-8648-
dc.identifier.pmid14978352-
dc.subject.keywordtegaserod-
dc.subject.keywordperistalsis-
dc.subject.keywordIleum (guinea pig)-
dc.subject.keywordprokinetic action-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameLee, Sang In-
dc.contributor.alternativeNameLee, Young Ho-
dc.contributor.alternativeNameChung, Jun Pyo-
dc.contributor.alternativeNameJi, Sang Won-
dc.rights.accessRightsfree-
dc.citation.volume94-
dc.citation.number2-
dc.citation.startPage144-
dc.citation.endPage152-
dc.identifier.bibliographicCitationJOURNAL OF PHARMACOLOGICAL SCIENCES, Vol.94(2) : 144-152, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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