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Effects of tegaserod on ileal peristalsis of guinea pig in vitro

Authors
 Sang Won Ji  ;  Hyojin Park  ;  Young Ho Lee  ;  Sang In Lee  ;  Jun Pyo Chung 
Citation
 JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol.94(2) : 144-152, 2004 
Journal Title
 JOURNAL OF PHARMACOLOGICAL SCIENCES 
ISSN
 1347-8613 
Issue Date
2004
MeSH
Animals ; Dose-Response Relationship, Drug ; Gastrointestinal Agents/pharmacology* ; Guinea Pigs ; Ileum/drug effects* ; Ileum/physiology ; In Vitro Techniques ; Indoles/pharmacology* ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/physiology ; Male ; Perfusion/instrumentation ; Perfusion/methods ; Peristalsis/drug effects* ; Peristalsis/physiology
Keywords
tegaserod ; peristalsis ; Ileum (guinea pig) ; prokinetic action
Abstract
The mechanisms of prokinetic action of tegaserod in the gastrointestinal tract has not been studied in detail. The aim of this study was to investigate the effect of tegaserod on peristaltic reflexes and propagating peristaltic waves in guinea pig ileum. A partitioned organ bath divided into three chambers was used to investigate the effect of tegaserod on peristaltic reflexes. A sensory stimulus was applied to the intermediate chamber, and changes in the circular muscle tension were monitored in a peripheral chamber. Another peristaltic bath was used to investigate the effect of tegaserod on peristaltic waves induced by intraluminal perfusion. Guinea pig ileum exhibited contractions in the circular muscle both orally and anally in response to mucosal stroking. Tegaserod (10(-8) - 10(-6) M) did not influence the maximal amplitude and the area under the curve of contraction both orally and anally to a mucosal stimulus. Intraluminal perfusion of fluid containing tegaserod (10(-8) - 10(-6) M) significantly increased the number of peristaltic waves in a concentration-dependent manner (P<0.05). Also, tegaserod (10(-8) - 10(-6) M) significantly increased the area under the curve of peristaltic waves (P<0.05). It is concluded that tegaserod has prokinetic action on guinea pig ileum by increasing the number of the circular muscle contractions during peristalsis.
Files in This Item:
T200400947.pdf Download
DOI
10.1254/jphs.94.144
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Chung, Jun Pyo(정준표)
Ji, Sang Won(지상원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112484
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