Cited 2 times in
Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 오영준 | - |
dc.date.accessioned | 2015-07-14T17:14:20Z | - |
dc.date.available | 2015-07-14T17:14:20Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112482 | - |
dc.description.abstract | BACKGROUND: Jugular bulb oxygen saturation (Sjv(o(2))) is a surrogate marker for global cerebral oxygenation. The effect of milrinone on Sjv(o(2)) and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T(1); Pa(co(2))=4.7-5.0 kPa) and hyperventilation (at T(2); Pa(co(2))=3.3-3.7 kPa) were induced and the changes in Sjv(o(2)) (DeltaSjv(o(2))) and Pa(co(2)) (DeltaPa(co(2))), and DeltaSjv(o(2))/DeltaPa(co(2)) (CCO(2)R) were measured. After normoventilation was re-established (at T(3)), milrinone 50 microg kg(-1) was given (at T(4)), followed by hyperventilation (at T(5)), and DeltaSjv(o(2)), DeltaPa(co(2)) and CCO(2)R were measured. RESULTS: After milrinone administration at normoventilation (T(3) and T(4)), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in Sjv(o(2)). Before milrinone administration (T(1) and T(2)), hyperventilation decreased Pa(co(2)) and Sjv(o(2)), and DeltaSjv(o(2)) showed positive linear correlation with DeltaPa(co(2)). After milrinone administration (T(4) and T(5)), hyperventilation decreased Pa(co(2)) and Sjv(o(2)), and DeltaSjv(o(2)) showed positive linear correlation with DeltaPa(co(2)). There was no significant difference in CCO(2)R before and after milrinone administration (13.3 (5.7)% kPa(-1) and 12.3 (3.9)% kPa(-1), respectively). CONCLUSIONS: Although milrinone induced significant haemodynamic changes, Sjv(o(2)) and CCO(2)R were unchanged during its administration. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 634~638 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carbon Dioxide/blood* | - |
dc.subject.MESH | Cardiac Output/drug effects | - |
dc.subject.MESH | Cardiotonic Agents/pharmacology* | - |
dc.subject.MESH | Cerebrovascular Circulation/drug effects | - |
dc.subject.MESH | Coronary Artery Bypass* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodynamics/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraoperative Care/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Milrinone/pharmacology* | - |
dc.subject.MESH | Monitoring, Intraoperative/methods | - |
dc.subject.MESH | Oxygen/blood* | - |
dc.subject.MESH | Partial Pressure | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Vasodilator Agents/pharmacology | - |
dc.title | Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Y. J. Oh | - |
dc.contributor.googleauthor | S. H. Kim | - |
dc.contributor.googleauthor | Y. L. Kwak | - |
dc.contributor.googleauthor | Y. W. Hong | - |
dc.contributor.googleauthor | C. S. Lee | - |
dc.contributor.googleauthor | H. K. Shinn | - |
dc.identifier.doi | 10.1093/bja/aeh252 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 15347605 | - |
dc.subject.keyword | anaesthesia, cardiac | - |
dc.subject.keyword | carbon dioxide, hypocarbia | - |
dc.subject.keyword | monitoring, jugular bulb oxygen saturation | - |
dc.subject.keyword | pharmacology, milrinone | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 93 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 634 | - |
dc.citation.endPage | 638 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.93(5) : 634-638, 2004 | - |
dc.identifier.rimsid | 56203 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.