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한국남성에서 전립선암의 선별을 위한 유리 전립선특이항원 비율 절단치의 임상적 적용
DC Field | Value | Language |
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dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-07-14T17:11:49Z | - |
dc.date.available | 2015-07-14T17:11:49Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112399 | - |
dc.description.abstract | Purpose: Whether the free to total prostate specific antigen (PSA) ratio (F/T PSA ratio) would enhance the detection of prostate cancer in Korean men with serum total PSA levels between 4 and 20ng/mul was evaluated. Materials and Methods: A total of 240 consecutive patients whose serum PSA levels were between 4 and 20ng/mul were enrolled in our recent two-year study. All patients underwent ultrasound-guided transrectal biopsies of the prostate gland. The F/T PSA ratio was measured using the Roche immunoassay (Roche Diagnostics GmbH, Manheim, Germany). Results: Of the 240 patients, 202 (84&) had a benign histology, while 38 (16&) had prostate cancer. The two patient groups were well matched for age. The mean F/T PSA ratio showed a statistically significant difference between the two groups: the benign histology group was 0.14 (0.04-0.37) and the prostate cancer group was 0.10 (0.08-0.20) (p<0.05). Out of the 183 patients in the group with PSA levels of 4-10ng/mul, the F/T PSA ratios were 0.14 and 0.11 in the benign histology (n=158) and prostate cancer (n=25) groups, respectively (p<0.05). From the 57 patients with the PSA level of 10-20ng/mul, the F/T PSA ratios were 0.14 and 0.10 in the benign histology (n=44) and prostate cancer (n=13) groups, respectively (p<0.05). Overall, when the cut-off value of the F/T PSA ratio was 0.10, the sensitivity and specificity were 75.0 and 76.5&, while for the a cut-off value of 0.15 they were 83.3 and 39.7&, respectively. Conclusions: Our data demonstrated the usefulness of the free to total PSA ratio in distinguishing benign prostate disease and cancer disease, hence eliminating unnecessary biopsies. It is recommended that a cut-off value for the F/T PSA ratio (0.10) be applied to Korean men; this is lower than the value used in Western countries. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 753~757 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 한국남성에서 전립선암의 선별을 위한 유리 전립선특이항원 비율 절단치의 임상적 적용 | - |
dc.title.alternative | Clinical Application of Free to Total PSA Ratio in Detection of Prostate Cancer in Korean Men : Lower Cut-off Value | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | 임영재 | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.contributor.googleauthor | 정병하 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02135 | - |
dc.subject.keyword | Prostatic neoplasm | - |
dc.subject.keyword | Biopsy | - |
dc.subject.keyword | Prostate-specific antigen | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 753 | - |
dc.citation.endPage | 757 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.45(8) : 753-757, 2004 | - |
dc.identifier.rimsid | 36290 | - |
dc.type.rims | ART | - |
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