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중증근무력증 환자의 CTLA-4 유전자 다형성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원주 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 이진성 | - |
dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2015-07-14T17:08:35Z | - |
dc.date.available | 2015-07-14T17:08:35Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112292 | - |
dc.description.abstract | Background: Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) plays a role in down-regulating both the cellular and the humoral responses by suppressing the ongoing responses of activated T-cells. There are evidences to suggest the genetic contribution of the CTLA-4 locus to a number of autoimmune diseases, such as insulin dependent diabetes mellitus, multiple sclerosis and systemic lupus erythematosus. The aim of the present study is to analyze CTLA-4 gene polymorphism in patients with myasthenia gravis (MG) compared to healthy controls. Methods: Thirty healthy controls and 31 patients with MG were genotyped into G/G, A/G and A/A of CTLA-4 gene polymorphism at position 49 and the relationship with the clinical feature was analysed. Results: In the patients with MG, the genotype frequencies of G/G, A/G and A/A were 61.3%, 35.5% and 3.2%, respectively. In healthy controls, the frequencies of each genotype were 50%, 43% and 7%, respectively. There was no significant difference in the genotype frequencies of CTLA-4 gene between patients with MG and the control group. There were also no significant differences in the genotype frequencies of CTLA-4 gene between ocular and generalized MG. Conclusions: These data suggest that the CTLA-4 polymorphism at position 49 do not affect the development of MG. However, further study is needed to clarify the possible role of the CTLA-4 polymorphism in the susceptibility to MG. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 504~507 | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 중증근무력증 환자의 CTLA-4 유전자 다형성 | - |
dc.title.alternative | CTLA-4 Polymorphism in Myasthenia Gravis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 박지형 | - |
dc.contributor.googleauthor | 이철호 | - |
dc.contributor.googleauthor | 최영철 | - |
dc.contributor.googleauthor | 이경열 | - |
dc.contributor.googleauthor | 김원주 | - |
dc.contributor.googleauthor | 김현숙 | - |
dc.contributor.googleauthor | 이진성 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01835 | - |
dc.subject.keyword | Cytotoxic T lymphocyte antigen-4 | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Myasthenia gravis | - |
dc.contributor.alternativeName | Kim, Won Joo | - |
dc.contributor.alternativeName | Kim, Hyun Sook | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Lee, Jin Sung | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 504 | - |
dc.citation.endPage | 507 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association, Vol.22(5) : 504-507, 2004 | - |
dc.identifier.rimsid | 38030 | - |
dc.type.rims | ART | - |
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