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인체 기관지 상피세포에서 Mycoplasma pneumoniae 항원이 IL-8 유전자 발현에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 권병철 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 최성연 | - |
dc.date.accessioned | 2015-07-14T17:05:57Z | - |
dc.date.available | 2015-07-14T17:05:57Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1225-679X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112203 | - |
dc.description.abstract | Purpose : Mycoplasma pneumoniae is a common cause of lower respiratory disease. Several studies have suggested that M. pneumoniae respiratory infection is associated with re-active airway disease and asthma. It has been suggested that Interleukin-8(IL-8) has a role in the pathogenesis of allergic inflammation of bronchial asthma and is well known to be expressed in bronchial epithelial cells. Methods : In this study, we examined the effect of M pneumoniae extract and the role of mitogen-activated protein kinases(MAPKs) on IL-8 expression in human lung epithelial cells. IL-8 levels were determined by an enzyme linked-immunosorbent assay. Extracellular signal-regulated kinase(ERK) phosphorylation was assessed by western blotting. Results : In A549 cells, AT. pneumoniae extract induced IL-8 release in a tame- or dose-dependent manner. Pretreatment with PD98059, which blocks the activation of MAPK/ERK kinase 1, before M. pneumoniae extract stimulation inhibited the increase in the production of IL-8 by 64.4% at 25 M. Stimulation of A549 cells by extract caused an increase in the activity of ERK, compared with the non-stimulated cells. The extract stimulation had no effect on the activities of p38. Conclusion : These observations suggest that activation of ERK by M. pneumoniae ex-tract may be one of the mechanisms that result in the increase of the production of IL-8. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 38~45 | - |
dc.relation.isPartOf | Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 인체 기관지 상피세포에서 Mycoplasma pneumoniae 항원이 IL-8 유전자 발현에 미치는 영향 | - |
dc.title.alternative | Effect of Mycoplasma pneumoniae on IL-8 Gene Expression in Human Respiratory Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 손명현 | - |
dc.contributor.googleauthor | 이경은 | - |
dc.contributor.googleauthor | 김규언 | - |
dc.contributor.googleauthor | 장명웅 | - |
dc.contributor.googleauthor | 장광천 | - |
dc.contributor.googleauthor | 김우경 | - |
dc.contributor.googleauthor | 권병철 | - |
dc.contributor.googleauthor | 최성연 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02476 | - |
dc.subject.keyword | Mycoplasma pneumoniae | - |
dc.subject.keyword | Interleukin-8 | - |
dc.subject.keyword | Respiratory epithelial cells | - |
dc.contributor.alternativeName | Kwon, Byoung Chul | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Choi, Sung Yon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.14(1) : 38-45, 2004 | - |
dc.identifier.rimsid | 45439 | - |
dc.type.rims | ART | - |
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