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신질환 환아에서 Cyclosporine A의 약동학 특성 및 치료효과
DC Field | Value | Language |
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dc.contributor.author | 박민수 | - |
dc.contributor.author | 이재승 | - |
dc.date.accessioned | 2015-07-14T17:02:33Z | - |
dc.date.available | 2015-07-14T17:02:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112089 | - |
dc.description.abstract | Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and closing of 12 months' CsA therapy. Results : The steady state CsA pharmacokinetic parameters of 34 patients were as follows; Tmax : 1.64?.84 hr, Cmax : 788?54 ng/dL, C12 : 58.7?3.2 ng/mL, Cavg : 246?6 ng/mL, AUC : 2,949?,156 ng hr/mL, Vd : 4.03?.45 L/kg, CL : 9.69?.27 L/hr, T1/2 : 5.31?.37 hr. C2 was the best to predict the CsA AUC(R=0.896, P<0.001). Body surface area based dosage(mg/m2/d) correlates best with AUC. Intra-individual CsA pharmacokinetic changes were not found after 12 months' therapy. Anti- proteinuric effect of CsA was considerable; 88.9% of primary nephrotic syndrome and 62.5% of secondary glomerular diseases was responsive to CsA thearpy. There was no serious complication and CsA treatment was well tolerated by the pediatric patients. Conclusion : CsA therapy for difficult renal diseases with proteinuria was effective and safe. For better AUC prediction of CsA, body surface area based dosage(mg/m2/d) and C2 monitoring are recommended in children with renal diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 193~203 | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 신질환 환아에서 Cyclosporine A의 약동학 특성 및 치료효과 | - |
dc.title.alternative | Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 전우성 | - |
dc.contributor.googleauthor | 박민수 | - |
dc.contributor.googleauthor | 배기수 | - |
dc.contributor.googleauthor | 박문성 | - |
dc.contributor.googleauthor | 유재은 | - |
dc.contributor.googleauthor | 이재승 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02100 | - |
dc.identifier.eissn | 2092-7258 | - |
dc.subject.keyword | Cyclosporine A | - |
dc.subject.keyword | Pharmacokinetics | - |
dc.subject.keyword | Nephrotic syndrome | - |
dc.subject.keyword | Glomerular diseases | - |
dc.subject.keyword | AUC(area under the time-concentration curve) | - |
dc.subject.keyword | Body surface area based dosage(mg/m²/d) | - |
dc.subject.keyword | C₂ monitoring | - |
dc.subject.keyword | Anti-proteinuric effect | - |
dc.contributor.alternativeName | Park, Min Soo | - |
dc.contributor.alternativeName | Lee, Jae Seung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 203 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, Vol.47(2) : 193-203, 2004 | - |
dc.identifier.rimsid | 52943 | - |
dc.type.rims | ART | - |
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