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수술후 급성 동통에 대한 Tramadol/Acetaminophen과 Codeine/Acetaminophen/Ibuprofen의 효과 발현시점과 진통효과의 비교
DC Field | Value | Language |
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dc.contributor.author | 김동기 | - |
dc.contributor.author | 김문기 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 이의웅 | - |
dc.contributor.author | 정영수 | - |
dc.contributor.author | 차인호 | - |
dc.date.accessioned | 2015-07-14T17:02:05Z | - |
dc.date.available | 2015-07-14T17:02:05Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1225-1585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112074 | - |
dc.description.abstract | Background: Some clinical trials have reported that a new analgesic combination of tramadol and acetaminophen provides good efficacy in various pain models. For the more clinical uses of this agent, comparisons about the onset of analgesia and analgesic efficacy in the acute state of pain with the other drugs known as strong analgesics were needed. Purpose: The goal of this study was to compare the times to onset of analgesia and the other analgesic efficacy of 75 mg tramadol/650 mg acetaminophen and 20 mg codeine/500 mg acetaminophen/400 mg ibuprofen in the treatment of acute pain after oral surgery. Patients and Methods: Using a randomized, single-dose, parallel-group, single-center, and active-controlled test design, this clinical study compared the times to onset of analgesia using a two-stopwatch technique and the other analgesic efficacy of the single-dose tramadol/ acetaminophen and odeine/acetaminophen/ibuprofen. These were assessed in 128 healthy subjects with pain from oral surgical procedures involving extraction of one or more impacted third molars requiring bone removal. From the time of pain development, the times to onset of perceptible and meaningful pain relief, pain intensity, pain relief, an overall assessment, and adverse events of the study medications were recorded for 6 hours. Results: The demographic distribution and baseline pain data in the two groups were statistically similar. The median times to onset of perceptible pain relief were 21.0 and 24.4 minutes in the tramadol/acetaminophen and codeine/acetaminophen/ibuprofen groups respectively and those to onset of meaningful pain relief were 56.4 and 57.3 minutes, which were statistically similar. The other efficacy variables such as mean total pain relief (TOTPAR) and the sum of pain intensity differences (SPID) were also similar in the early period after pain development and drug dosing. The safety of tramadol/acetaminophen was well tolerated and very comparable to that of codeine/acetaminophen/ibuprofen. Conclusions: In this acute dental pain model, the onset of analgesia and analgesic efficacy of tramadol/acetaminophen was comparable to that of codeine/acetaminophen/ibuprofen. These results showed that tramadol/acetaminophen was recommendable for fast and effective treatment in the management of postoperative acute pain. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 143~149 | - |
dc.relation.isPartOf | Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 수술후 급성 동통에 대한 Tramadol/Acetaminophen과 Codeine/Acetaminophen/Ibuprofen의 효과 발현시점과 진통효과의 비교 | - |
dc.title.alternative | Comparison of tramadol/acetaminophen and odeine/acetaminophen/ibuprofen in onset of analgesia and analgesic efficacy for postoperative acute pain | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery (구강악안면외과학) | - |
dc.contributor.googleauthor | 정영수 | - |
dc.contributor.googleauthor | 김동기 | - |
dc.contributor.googleauthor | 이의웅 | - |
dc.contributor.googleauthor | 한무영 | - |
dc.contributor.googleauthor | 차인호 | - |
dc.contributor.googleauthor | 김형준 | - |
dc.contributor.googleauthor | 김문기 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01806 | - |
dc.subject.keyword | Analgesic combination | - |
dc.subject.keyword | Analgesic efficacy | - |
dc.subject.keyword | Onset of analgesia | - |
dc.subject.keyword | Tramadol/acetaminophen | - |
dc.subject.keyword | Postoperative pain | - |
dc.contributor.alternativeName | Kim, Dong Ki | - |
dc.contributor.alternativeName | Kim, Moon Key | - |
dc.contributor.alternativeName | Kim, Hyung Jun | - |
dc.contributor.alternativeName | Lee, Eui Wung | - |
dc.contributor.alternativeName | Jung, Young Soo | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 149 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.30(2) : 143-149, 2004 | - |
dc.identifier.rimsid | 52932 | - |
dc.type.rims | ART | - |
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