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상피성 난소암에서 핵 DNA 정량검사와 cyclin A의 예후적 의의
DC Field | Value | Language |
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dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재욱 | - |
dc.contributor.author | 노종환 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2015-07-14T17:00:37Z | - |
dc.date.available | 2015-07-14T17:00:37Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1738-5628 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112026 | - |
dc.description.abstract | Objective: This study was carried out to investigate the relationship between DNA ploidy, S-phase fraction (SPF), expression of cyclin A and clinical prognostic factors including stage, grade, CA-125 and residual tumor size in epithelial ovarian cancer, and to evaluate the association between DNA ploidy, SPF, expression of cyclin A and 3-year survival. Methods: Study group consisted of 31 cases of epithelial ovarian cancer, 10 of borderline ovarian tumor and 5 of benign ovarian tumor diagnosed at the department of Obstet. and Gynecol. in Yonsei University College of Medicine, Seoul, Korea from Feb. 2000 to Jan. 2003. All patients underwent staging-laparotomy and postoperative chemotherapy. The level of CA-125 was assessed after 6th postoperative chemotherapy with cut-off value of 35 U/mL. DNA ploidy and SPF were evaluated by flow-cytometry of fresh ovarian tissue obtained at the operative field. The expression of cyclin A was evaluated by immuno-histochemical stain. Expression of 5% was considered as positive. Statistical analysis was done by two-sample t-test, chi-square test, and Kaplan-Meier survival curve using SPSS ver 11.0 software. Results: In 46 ovarian tumors aneuploidy, SPF and expression of cyclin A were significantly higher in epithelial ovarian cancer as compared with benign and borderline tumors (p=0.004, 0.001, 0.001, respectively). Number of aneuploidy, SPF and expression of cyclin A were significantly higher in patients with higher grade, more advanced stage, higher level of CA-125 (more than 35 U/mL) and more than 2 cm of residual tumor size (p=0.004, 0.009, 0.05, 0.002 in aneuploidy; p=0.06, 0.01, 0.04, 0.007 in SPF; p=0.03, 0.004, 0.06, 0.02 in cyclin A). Aneuploidy and expressions of more than 10% of SPF and cyclin A were also associated with poorer overall survival (p=0.02, 0.02, <0.0001, respectively). Significantly positive correlations were observed among these factors. Conclusion: Number of aneuploidy, percentage of SPF and expression of cyclin A were higher in more advanced stage, higher grade, higher CA-125 and more than 2 cm of residual tumor size and associated with poorer overall survival. Thus DNA flow-cytometry and estimation of expression of cyclin A may provide major information about prognosis of disease in epithelial ovarian cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1309~1316 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 상피성 난소암에서 핵 DNA 정량검사와 cyclin A의 예후적 의의 | - |
dc.title.alternative | Prognostic Value of Nuclear DNA Quantification and Cyclin A in Epithelial Ovarian Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | 이종승 | - |
dc.contributor.googleauthor | 조남훈 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.googleauthor | 노종환 | - |
dc.contributor.googleauthor | 김성훈 | - |
dc.contributor.googleauthor | 김영태 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02075 | - |
dc.subject.keyword | Flow-cytometry | - |
dc.subject.keyword | DNA ploidy | - |
dc.subject.keyword | S-phase fraction | - |
dc.subject.keyword | Cyclin A | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Wook | - |
dc.contributor.alternativeName | Roh, Jong Hwan | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1309 | - |
dc.citation.endPage | 1316 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.47(7) : 1309-1316, 2004 | - |
dc.identifier.rimsid | 52895 | - |
dc.type.rims | ART | - |
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