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사람의 제2형 당뇨병성 신증의 신조직내 TGF-β-inducible Gene-h3의 발현과 유용성-면역조직화학적 분석-
DC Field | Value | Language |
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dc.contributor.author | 임범진 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-07-14T17:00:16Z | - |
dc.date.available | 2015-07-14T17:00:16Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1225-0015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112014 | - |
dc.description.abstract | Background: Activation of transforming growth factor-β (TGF-β) system has been implicated in the pathological change of diabetic nephropathy such as renal hypertrophy and accumulation of extracellular matrix. In tissues, TGF-β is secreted as a biologically inactive complex requiring in vivo activation. Thus, increased TGF-β1 mRNA or protein may not necessarily reflect parallel changes in TGF-β1 biologic activity. TGF-β1 inducible gene-h3 (βig-h3) is a novel gene uniquely up-regulated by active TGF-β1. Methods: For evaluating the βig-h3 protein expression in human diabetic nephropathy, we examed the expression of βig-h3 protein, TGF-β1, TGF-β type II receptor (TRII) and Smad protein intranuclear translocation by immunohistochemistry in human diabetic nephropathy tissues (n=11) and normal renal tissue (n=3). Results: The βig-h3 protein was expressed in diabetic tubular epithelium (diabetes vs. normal 7/11 vs. 0/3) and diabetic glomerulus (diabetes vs. normal 5/11 vs. 0/3). The tubular expression was stronger than the interstitial expression. The TGF-β1 was expressed in diabetic tubular epithelium (diabetes vs. normal 1/11 vs. 0/3) and diabetic glomerulus (diabetes vs. normal 3/11 vs. 0/3). The TGF-β type II was expressed more in diabetic glomerulus (diabetes vs normal 6/11 vs. 1/3). But in the tubule, the expression didn’t show any significant difference. The number of intranuclear translocation of Smad protein in glomerulus (diabetes vs normal 49.1±0.3 vs. 40.1±0.8) was increased in diabetes, but the tubular manifestation was not significant. Conclusion: We propose that TGF-β system mediates human diabetic nephropathy through βig- h3 protein expression. The βig-h3 protein expression could be a useful marker expecting of disease activity and progress. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 559~566 | - |
dc.relation.isPartOf | Korean Journal of Nephrology (대한신장학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 사람의 제2형 당뇨병성 신증의 신조직내 TGF-β-inducible Gene-h3의 발현과 유용성-면역조직화학적 분석- | - |
dc.title.alternative | Renal Expression and Usefulness of TGF-β-inducible Gene-h3 in Human Type II Diabetic Nephropathy -Immunohistochemical Analysis- | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | 홍순원 | - |
dc.contributor.googleauthor | 임범진 | - |
dc.contributor.googleauthor | 윤희정 | - |
dc.contributor.googleauthor | 이동신 | - |
dc.contributor.googleauthor | 정현주 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02066 | - |
dc.subject.keyword | Diabetic nephropathy | - |
dc.subject.keyword | Human | - |
dc.subject.keyword | TGF-β | - |
dc.subject.keyword | βig-h3 protein | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 559 | - |
dc.citation.endPage | 566 | - |
dc.identifier.bibliographicCitation | Korean Journal of Nephrology (대한신장학회지), Vol.23(4) : 559-566, 2004 | - |
dc.identifier.rimsid | 52888 | - |
dc.type.rims | ART | - |
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