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사람 구강암종 세포주에서 Non-Steroidal Anti-Inflammatory Drug-Activated Gene(NAG-1)의 유도 및 세포고사 작용

DC FieldValueLanguage
dc.contributor.author김경수-
dc.contributor.author윤주헌-
dc.contributor.author이정권-
dc.contributor.author이주환-
dc.date.accessioned2015-07-14T17:00:12Z-
dc.date.available2015-07-14T17:00:12Z-
dc.date.issued2004-
dc.identifier.issn1225-035X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112012-
dc.description.abstractBackground and Objectives:Nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1), which is induced by NSAIDs, has proapoptotic and antitumorigenic effects in colorectal cancer cells. However, NAG-1 induction and its effect on the apoptosis in human oral cavity cancer cells (SCC 1483) have not been determined. Materials and Method:NAG-1 expression by various NSAIDs in SCC 1483 cells was investigated by Western blot analysis. The induction of apoptosis by NSAID and the relationship between NAG-1 expression and apoptosis were determined by Western blot assay and flow cytometry. Drosophila cells stably expressing NAG-1 were constructed and NAG-1 conditioned medium (NCM) were made. Apoptosis was examined with flow cytometry on SCC 1483 cells treated with NCM. Results:Diclofenac was the most potent inducer of NAG-1. Diclofenac inhibited the proliferation of SCC 1483 cells and this inhibition was proved as apoptosis. Diclofenac induced the expression of NAG-1 and also induced apoptosis in time and dose dependent manner. In the concentrated NCM, the expression of NAG-1 was intense and apoptosis was induced by addition of 5 μl of NCM. Conclusion:Based on these data, we could assure that NSAIDs induced NAG-1 in oral cavity cancer cells and NAG-1 induced apoptosis. Therefore, we suggest that it is possible to use NSAIDs as a chemopreventive agent in oral cavity cancer. Further studies on the mechanism of NAG-1 and clinical use will be needed.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1030~1037-
dc.relation.isPartOfKorean Journal of Otolaryngology (대한이비인후과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title사람 구강암종 세포주에서 Non-Steroidal Anti-Inflammatory Drug-Activated Gene(NAG-1)의 유도 및 세포고사 작용-
dc.title.alternativeInduction of Non-Steroidal Anti-Inflammatory Drug-Activated Gene(NAG-1) in Human Oral Cavity Cancer Cells and its Effect on Apoptosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthor이주환-
dc.contributor.googleauthor윤주헌-
dc.contributor.googleauthor김경수-
dc.contributor.googleauthor이윤재-
dc.contributor.googleauthor장정현-
dc.contributor.googleauthor이정권-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02088-
dc.subject.keywordNon-steroidal anti-inflammatory agents-
dc.subject.keywordOral cancers-
dc.subject.keywordApoptosis-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Jeung Gweon-
dc.contributor.alternativeNameLee, Joo Hwan-
dc.rights.accessRightsfree-
dc.citation.volume47-
dc.citation.number10-
dc.citation.startPage1030-
dc.citation.endPage1037-
dc.identifier.bibliographicCitationKorean Journal of Otolaryngology (대한이비인후과학회지), Vol.47(10) : 1030-1037, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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