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당뇨병 환자에서 산화 스트레스에 의한 NF-κB 및 AP-1의 활성화가 죽상동맥경화증에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 차봉수 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 김똘미 | - |
dc.contributor.author | 김철식 | - |
dc.contributor.author | 남주영 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 박진아 | - |
dc.contributor.author | 안철우 | - |
dc.date.accessioned | 2015-07-14T16:56:58Z | - |
dc.date.available | 2015-07-14T16:56:58Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1976-9180 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111906 | - |
dc.description.abstract | Background: The aim of this study was to evaluate the possible role of NF- B activation and AP-1 by oxidative stress in atherosclerosis in diabetic patients by measuring the carotid intima-media thickness, intracellular ROS generation and activation of transcription factors, including nuclear factor-kappa B (NF- B) and activator protein-1 (AP-1). Methods: Sixty-six patients (28 males, 38 females; age 56.1 13.4 years; duration of diabetes 115.7 83.4 months) with type 2 diabetes mellitus (DM) were selected for this study. The DM patients included in this study were divided into those with a normal carotid intima-media thickness (Group II) and those with an increased intima-media thickness (Group III). 57 healthy controls matched for age and sex with the DM patients (Group I) were randomly selected. Dichlorodifluorescein (DCF)-sensitive intracellular ROS was measured by fluorescent spectrometry. The activities of NF- B and AP-1 in PBMCs were measured by an electrophoretic mobility shift assay. Results: No differences were evident between the groups in terms of gender, age, BMI, blood pressure, total cholesterol, triglyceride, LDL-cholesterol and HDL-cholesterol. Spontaneous and H2O2 (or phorbol-12-myristate-13-acetate, PMA) stimulated ROS were significantly higher in the PBMCs from the DM patients with an increased intima-media thickness (Group III) than in those without (Group II), and were also higher in the control group (Group I). Moreover, the activities of NF- B and AP-1 were significantly higher in Group III than in Groups I or II. Conclusion: The present study demonstrates that intracellular ROS generation, and NF- B and AP-1 activation in PBMCs strongly correlates with the carotid artery IMT. These clinical results suggest that increased oxidative stress in PBMCs may play a role in the pathogenesis of atherosclerosis in DM patients | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 255~264 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 당뇨병 환자에서 산화 스트레스에 의한 NF-κB 및 AP-1의 활성화가 죽상동맥경화증에 미치는 영향 | - |
dc.title.alternative | Role of Activation of NF- B and AP-1 by Oxidative Stress in Atherosclerosis in Diabetic Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 김철식 | - |
dc.contributor.googleauthor | 이근택 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 김똘미 | - |
dc.contributor.googleauthor | 박종숙 | - |
dc.contributor.googleauthor | 남주영 | - |
dc.contributor.googleauthor | 조민호 | - |
dc.contributor.googleauthor | 박진아 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01508 | - |
dc.subject.keyword | NF- B | - |
dc.subject.keyword | AP-1 | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Intima κ media thickness | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Kim, Dol Mi | - |
dc.contributor.alternativeName | Kim, Chul Sik | - |
dc.contributor.alternativeName | Nam, Ju Young | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Park, Jina | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 264 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.28(4) : 255-264, 2004 | - |
dc.identifier.rimsid | 53505 | - |
dc.type.rims | ART | - |
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