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극소저출생체중아에서 발생한 만성 폐질환에서 양압 환기법의 누적 효과

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dc.contributor.author남궁란-
dc.contributor.author박민수-
dc.contributor.author이철-
dc.date.accessioned2015-07-14T16:55:02Z-
dc.date.available2015-07-14T16:55:02Z-
dc.date.issued2004-
dc.identifier.issn1226-1513-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111842-
dc.description.abstractPurpose : Barotrauma is one of the most important risk factors of chronic lung disease (CLD) in neonates. However, so-often called ´high pressure´ does not specify the magnitude or duration of positive pressure ventilation in relation to development of CLD. We investigated whether cumulative effect of positive pressure ventilation over time was more closely associated with CLD than the magnitude of maximal peak inspiratory pressure (PIP) or mean airway pressure (MAP). Methods : Clinical data were collected from 53 very low birth weight (VLBW) infants (24; CLD and 29; non-CLD) who were treated with mechanical ventilation due to respiratory distress syndrome (RDS) at the neonatal intensive care unit (NICU) in Yonsei University Medical Center. Areas under the pressure-time curve for peak inspiratory pressure (AUCPIP), mean airway pressure (AUCMAP), and FiO2 (AUCFiO2) were calculated from hourly changes of the ventilatory parameters plotted against time during the first 5 days of life, and were compared with the magnitudes of episodic, maximum PIP, MAP or FiO2. Results : The AUCMAP and AUCPIP in CLD group was significantly higher than in non-CLD group (639.8±142.9 cmH2O‧hr vs. 474.2±148.0 cmH2O‧hr, P<0.001 1412.2±480.3 cmH2O‧hr vs. 992.7±517.0 cmH2O‧hr, P=0.004, respectively). But there were no significant differences between two groups in maximum MAP and maximum PIP (P> 0.05). After statistical correction for independent factors related to development of CLD, AUCMAP was shown to be most meaningful. Conclusion : Our data are suggestive of the importance of cumulative barotrauma over time in CLD rather than episodic barotrauma caused by cross-sectional or intermittent high peak pressures.-
dc.description.statementOfResponsibilityopen-
dc.format.extent54~64-
dc.languageJournal of the Korean Society of Neonatology-
dc.publisherJournal of the Korean Society of Neonatology-
dc.relation.isPartOfJournal of the Korean Society of Neonatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title극소저출생체중아에서 발생한 만성 폐질환에서 양압 환기법의 누적 효과-
dc.title.alternativeCumulative Effects of Positive Pressure Ventilation on the Development of Chronic Lung Disease in Very Low Birth Weight Infants-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor강보훈-
dc.contributor.googleauthor윤지현-
dc.contributor.googleauthor이철-
dc.contributor.googleauthor남궁란-
dc.contributor.googleauthor박민수-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01883-
dc.identifier.eissn2093-7849-
dc.subject.keywordChronic lung disease-
dc.subject.keywordvery low birth weigth infants-
dc.subject.keywordcumulative barotrauma-
dc.subject.keywordmean airway pressure-
dc.subject.keywordpeak inspiratory pressure-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameLee, Chul-
dc.rights.accessRightsfree-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage54-
dc.citation.endPage64-
dc.identifier.bibliographicCitationJournal of the Korean Society of Neonatology, Vol.11(1) : 54-64, 2004-
dc.identifier.rimsid47322-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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