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국내 대학병원 환자의 호흡기 검체에서 분리된 세균에 대한 Gatifloxacin의 시험관내 항균력

Other Titles
 In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea 
Authors
 용동은  ;  김명숙  ;  이일섭  ;  정윤섭  ;  김성규  ;  이경원  ;  김신영 
Citation
 Infection and Chemotherapy (감염과 화학요법), Vol.36(2) : 68-74, 2004 
Journal Title
 Infection and Chemotherapy  (감염과 화학요법) 
ISSN
 1598-8112 
Issue Date
2004
Abstract
Background:Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals. Methods:Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method. Results:MIC90 of gatifloxacin for Streptococcus pneumoniae was 1 μg/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus influenzae and Moraxella (Branhamella) catarrhalis were inhibited by ≤0.06 μg/mL and ≤0.25 μg/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MIC90 of gatifloxacin for Klebsiella pneumoniae was 0.06 μg/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin. Conclusion:Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김성규(Kim, Sung Kyu)
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
정윤섭(Chong, Yun Sop)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111835
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