Cited 13 times in
The human myotubularin-related protein suppresses the growth of lung carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | 김형중 | - |
dc.contributor.author | 장윤수 | - |
dc.contributor.author | 안철민 | - |
dc.date.accessioned | 2015-07-14T16:51:39Z | - |
dc.date.available | 2015-07-14T16:51:39Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111734 | - |
dc.description.abstract | Herein, we report that the human myotubularin-related protein (KIAA0371) induced growth suppression of lung cancer cells. Colony formation assays demonstrated that the exogenous expression of the human myotubularin-related gene induced a significant growth inhibition of H1299 cells in which the expression of the human myotubularin-related gene was undetectable. Colony formation of these cells was reduced by 39% after transfection with this gene, as compared with the control vector. Cells stably transfected with this gene showed a reduction in growth of 48% compared with those cells transfected with the empty vector. We also showed that this negative regulation of the myotubularin-related protein is correlated with cell-cycle arrest at G1. In addition, we found that the cyclin-dependent kinase inhibitor, p27, is induced by increased expression of the human myotubularin-related gene. These results suggest that the human myotubularin-related protein can negatively regulate the growth of lung cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Blotting, Northern | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cell Cycle Proteins/metabolism | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Division | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Separation | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p27 | - |
dc.subject.MESH | DNA/chemistry | - |
dc.subject.MESH | DNA, Complementary/metabolism | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | G1 Phase | - |
dc.subject.MESH | Genetic Therapy/methods* | - |
dc.subject.MESH | Genetic Vectors | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoblotting | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Lung Neoplasms/therapy* | - |
dc.subject.MESH | Protein Tyrosine Phosphatases/genetics | - |
dc.subject.MESH | Protein Tyrosine Phosphatases/physiology* | - |
dc.subject.MESH | Protein Tyrosine Phosphatases, Non-Receptor | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Suppressor Proteins/metabolism | - |
dc.title | The human myotubularin-related protein suppresses the growth of lung carcinoma cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Do Yoo | - |
dc.contributor.googleauthor | Sun Mi Cho | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Chul Min Ahn | - |
dc.contributor.googleauthor | Yoon Soo Chang | - |
dc.contributor.googleauthor | Jun Suk Kim | - |
dc.identifier.doi | 10.3892/or.12.3.667 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 15289854 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/12/3/667 | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Ahn, Chul Min | - |
dc.contributor.alternativeName | Chang, Yoon Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 667 | - |
dc.citation.endPage | 671 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.12(3) : 667-671, 2004 | - |
dc.identifier.rimsid | 37437 | - |
dc.type.rims | ART | - |
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