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Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasia

Authors
 Seung-Koo Lee  ;  Dong Ik Kim  ;  Byung In Lee  ;  Kyoung Heo  ;  Heung Dong Kim  ;  Jinna Kim  ;  Susumu Mori 
Citation
 NEUROIMAGE, Vol.22(4) : 1826-1829, 2004 
Journal Title
 NEUROIMAGE 
ISSN
 1053-8119 
Issue Date
2004
MeSH
Adolescent ; Child ; Diffusion Magnetic Resonance Imaging* ; Female ; Frontal Lobe/abnormalities* ; Frontal Lobe/pathology ; Humans ; Image Processing, Computer-Assisted* ; Male ; Nerve Fibers/pathology* ; Nerve Net/abnormalities ; Nerve Net/pathology ; Occipital Lobe/abnormalities* ; Occipital Lobe/pathology ; Sensitivity and Specificity
Keywords
DTI ; Focal cortical dysplasia ; Fiber connectivity
Abstract
Diffusion tensor imaging (DTI) was applied to 12 patients with focal cortical dysplasia (FCD) in frontal or occipital cortex. Fiber tractography was obtained from seeding points in superior longitudinal fasciculus or posterior corona radiata. Mean fractional anisotropy of fiber bundles around the affected cortex was decreased in comparison to the contralateral hemisphere with statistical significance (paired t test, P = 0.0274). On visual analysis, tractography depicted decreased volume of fiber bundles connected to the dysplastic cortex invariably even in those with a normal T2 signal intensity of underlying white matter adjacent to FCD. DTI has high potential to be applied to localize the FCD and to provide a better understanding of the pathological changes in the white matter.
Full Text
http://www.sciencedirect.com/science/article/pii/S1053811904002368
DOI
10.1016/j.neuroimage.2004.04.028
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Byung In(이병인)
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111703
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