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Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors

DC Field Value Language
dc.contributor.author이배환-
dc.date.accessioned2015-07-14T16:50:27Z-
dc.date.available2015-07-14T16:50:27Z-
dc.date.issued2004-
dc.identifier.issn1044-7431-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111695-
dc.description.abstractThe levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R−/−) mice, which show a significant locomotor impairment. In this study, the effects of different GABAergic drugs on locomotor activity were analyzed in D2R−/− mice. After administering muscimol (1 mg/kg), a GABAA receptor agonist, the D2R−/− mice showed increased locomotor activity up to 200%. When the muscimol dose was increased (4–6 mg/kg), the D2R−/− mice exhibited seizure-like behavior, and the electroencephalographic (EEG) recordings during these behaviors showed a high amplitude rhythmic epileptiform activity in these mice. In situ hybridization showed that after injecting muscimol in the D2R−/− mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation. These results suggest that the absence of D2R alters the GABAergic neurotransmission, specifically on GABAA-receptor mediated signaling, and stimulating the GABAA receptor can reverse the dysfunction of GABAergic inhibition in the motor circuits in the basal ganglia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent732~741-
dc.relation.isPartOfMOLECULAR AND CELLULAR NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBasal Ganglia/drug effects-
dc.subject.MESHBasal Ganglia/metabolism*-
dc.subject.MESHBasal Ganglia/physiopathology-
dc.subject.MESHBrain Chemistry/genetics*-
dc.subject.MESHDopamine/metabolism-
dc.subject.MESHElectroencephalography/drug effects-
dc.subject.MESHEnkephalins/metabolism-
dc.subject.MESHGABA Agonists/pharmacology-
dc.subject.MESHGABA Antagonists/pharmacology-
dc.subject.MESHGABA-A Receptor Agonists-
dc.subject.MESHGABA-A Receptor Antagonists-
dc.subject.MESHGlutamate Decarboxylase/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMotor Activity/drug effects-
dc.subject.MESHMotor Activity/physiology-
dc.subject.MESHNeural Inhibition/drug effects-
dc.subject.MESHNeural Inhibition/physiology-
dc.subject.MESHReceptors, Dopamine D2/deficiency-
dc.subject.MESHReceptors, Dopamine D2/genetics*-
dc.subject.MESHReceptors, GABA-A/metabolism-
dc.subject.MESHSeizures/chemically induced-
dc.subject.MESHSeizures/enzymology-
dc.subject.MESHSynaptic Transmission/drug effects-
dc.subject.MESHSynaptic Transmission/physiology*-
dc.subject.MESHUp-Regulation/drug effects-
dc.subject.MESHUp-Regulation/physiology-
dc.subject.MESHgamma-Aminobutyric Acid/metabolism*-
dc.titleAltered GABAergic neurotransmission in mice lacking dopamine D2 receptors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorJuan Ji An-
dc.contributor.googleauthorMi-Hyun Bae-
dc.contributor.googleauthorJa-Hyun Baik-
dc.contributor.googleauthorEmiliana Borrelli-
dc.contributor.googleauthorKye Won Park-
dc.contributor.googleauthorYong Nyun Kim-
dc.contributor.googleauthorHee-Sup Shin-
dc.contributor.googleauthorBae Hwan Lee-
dc.contributor.googleauthorSeong-Hoon Choi-
dc.contributor.googleauthorSoo-Hyun Lee-
dc.contributor.googleauthorSang Rae Cho-
dc.identifier.doi10.1016/j.mcn.2003.12.010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02245-
dc.identifier.eissn1095-9327-
dc.identifier.pmid15080900-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1044743103004007-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.rights.accessRightsnot free-
dc.citation.volume25-
dc.citation.number4-
dc.citation.startPage732-
dc.citation.endPage741-
dc.identifier.bibliographicCitationMOLECULAR AND CELLULAR NEUROSCIENCE, Vol.25(4) : 732-741, 2004-
dc.identifier.rimsid37419-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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