Cited 23 times in
Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors
DC Field | Value | Language |
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dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2015-07-14T16:50:27Z | - |
dc.date.available | 2015-07-14T16:50:27Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1044-7431 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111695 | - |
dc.description.abstract | The levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R−/−) mice, which show a significant locomotor impairment. In this study, the effects of different GABAergic drugs on locomotor activity were analyzed in D2R−/− mice. After administering muscimol (1 mg/kg), a GABAA receptor agonist, the D2R−/− mice showed increased locomotor activity up to 200%. When the muscimol dose was increased (4–6 mg/kg), the D2R−/− mice exhibited seizure-like behavior, and the electroencephalographic (EEG) recordings during these behaviors showed a high amplitude rhythmic epileptiform activity in these mice. In situ hybridization showed that after injecting muscimol in the D2R−/− mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation. These results suggest that the absence of D2R alters the GABAergic neurotransmission, specifically on GABAA-receptor mediated signaling, and stimulating the GABAA receptor can reverse the dysfunction of GABAergic inhibition in the motor circuits in the basal ganglia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 732~741 | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Basal Ganglia/drug effects | - |
dc.subject.MESH | Basal Ganglia/metabolism* | - |
dc.subject.MESH | Basal Ganglia/physiopathology | - |
dc.subject.MESH | Brain Chemistry/genetics* | - |
dc.subject.MESH | Dopamine/metabolism | - |
dc.subject.MESH | Electroencephalography/drug effects | - |
dc.subject.MESH | Enkephalins/metabolism | - |
dc.subject.MESH | GABA Agonists/pharmacology | - |
dc.subject.MESH | GABA Antagonists/pharmacology | - |
dc.subject.MESH | GABA-A Receptor Agonists | - |
dc.subject.MESH | GABA-A Receptor Antagonists | - |
dc.subject.MESH | Glutamate Decarboxylase/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Motor Activity/drug effects | - |
dc.subject.MESH | Motor Activity/physiology | - |
dc.subject.MESH | Neural Inhibition/drug effects | - |
dc.subject.MESH | Neural Inhibition/physiology | - |
dc.subject.MESH | Receptors, Dopamine D2/deficiency | - |
dc.subject.MESH | Receptors, Dopamine D2/genetics* | - |
dc.subject.MESH | Receptors, GABA-A/metabolism | - |
dc.subject.MESH | Seizures/chemically induced | - |
dc.subject.MESH | Seizures/enzymology | - |
dc.subject.MESH | Synaptic Transmission/drug effects | - |
dc.subject.MESH | Synaptic Transmission/physiology* | - |
dc.subject.MESH | Up-Regulation/drug effects | - |
dc.subject.MESH | Up-Regulation/physiology | - |
dc.subject.MESH | gamma-Aminobutyric Acid/metabolism* | - |
dc.title | Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Juan Ji An | - |
dc.contributor.googleauthor | Mi-Hyun Bae | - |
dc.contributor.googleauthor | Ja-Hyun Baik | - |
dc.contributor.googleauthor | Emiliana Borrelli | - |
dc.contributor.googleauthor | Kye Won Park | - |
dc.contributor.googleauthor | Yong Nyun Kim | - |
dc.contributor.googleauthor | Hee-Sup Shin | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Seong-Hoon Choi | - |
dc.contributor.googleauthor | Soo-Hyun Lee | - |
dc.contributor.googleauthor | Sang Rae Cho | - |
dc.identifier.doi | 10.1016/j.mcn.2003.12.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02245 | - |
dc.identifier.eissn | 1095-9327 | - |
dc.identifier.pmid | 15080900 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1044743103004007 | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 732 | - |
dc.citation.endPage | 741 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR NEUROSCIENCE, Vol.25(4) : 732-741, 2004 | - |
dc.identifier.rimsid | 37419 | - |
dc.type.rims | ART | - |
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