Cited 26 times in
Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells
DC Field | Value | Language |
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dc.contributor.author | 김경섭 | - |
dc.date.accessioned | 2015-07-14T16:50:03Z | - |
dc.date.available | 2015-07-14T16:50:03Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111682 | - |
dc.description.abstract | We have characterized the role of Drosophila PI3K and AKT in ERK pathway activation involving insulin-induced proliferation using Drosophila Schneider cells. After insulin treatment, dPI3K and dAKT activities were both increased along with activation of the dERK pathway components dMEK and dERK. The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations. Proliferation and the G1 to S phase cell cycle progression due to insulin were also blocked by PI3K and AKT inhibitors, indicating that the Drosophila PI3K–AKT pathway involves insulin-mediated cell proliferation. The insulin-stimulated size increase was blocked by both LY294002 and AKT inhibitor, not by U0126, indicating that insulin-mediated size control by dPI3K and dAKT occurs independently of the ERK pathway. This study indicates that dPI3K and dAKT are involved in insulin-induced ERK pathway activation leading to proliferation in Drosophila Schneider cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1309~1317 | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Cycle/drug effects | - |
dc.subject.MESH | Cell Cycle/physiology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Proliferation/drug effects* | - |
dc.subject.MESH | Drosophila Proteins | - |
dc.subject.MESH | Drosophila melanogaster | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/drug effects | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism* | - |
dc.subject.MESH | G1 Phase/drug effects | - |
dc.subject.MESH | G1 Phase/physiology | - |
dc.subject.MESH | Insulin/metabolism* | - |
dc.subject.MESH | Insulin/pharmacology | - |
dc.subject.MESH | MAP Kinase Kinase 1/metabolism | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/metabolism* | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt | - |
dc.subject.MESH | S Phase/drug effects | - |
dc.subject.MESH | S Phase/physiology | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Signal Transduction/physiology | - |
dc.title | Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Sung-Eun Kim | - |
dc.contributor.googleauthor | Jae-Young Cho | - |
dc.contributor.googleauthor | Kang-Yell Choi | - |
dc.contributor.googleauthor | Ki-Hoo Lee | - |
dc.contributor.googleauthor | Su-Jae Lee | - |
dc.contributor.googleauthor | Kyung-Sup Kim | - |
dc.identifier.doi | 10.1016/j.cellsig.2004.04.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00502 | - |
dc.identifier.eissn | 1873-3913 | - |
dc.identifier.pmid | 15337530 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0898656804000609 | - |
dc.subject.keyword | Drosophila | - |
dc.subject.keyword | Insulin pathway | - |
dc.subject.keyword | PI3 kinase | - |
dc.subject.keyword | AKT | - |
dc.subject.keyword | Cell proliferation | - |
dc.contributor.alternativeName | Kim, Kyung Sup | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1309 | - |
dc.citation.endPage | 1317 | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, Vol.16(11) : 1309-1317, 2004 | - |
dc.identifier.rimsid | 37409 | - |
dc.type.rims | ART | - |
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