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Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes

 Eun Seok Kang  ;  Hae Jin Kim  ;  Hyun Chul Lee  ;  Hyung Jin Kim  ;  Sung Kil Lim  ;  Bong Soo Cha  ;  Sihoon Lee  ;  Yoo Mee Kim 
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.66(Suppl 1) : 115-120, 2004 
Journal Title
Issue Date
Adult ; Biomarkers/blood ; Blood Glucose/metabolism ; Blood Pressure ; Body Size ; C-Reactive Protein/metabolism* ; Carotid Arteries/pathology* ; Diabetes Mellitus, Type 2/blood* ; Diabetes Mellitus, Type 2/pathology* ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/pathology ; Female ; Humans ; Male ; Middle Aged ; Tunica Intima/pathology* ; Tunica Media/pathology*
High sensitivity C-reactive protein ; Carotid intima-media thickness ; Type 2 diabetes mellitus
BACKGROUND: High sensitivity C-reactive protein (hsCRP) is more sensitive than standard C-reactive protein (CRP) assay in evaluating the risk of coronary heart disease and other atherosclerotic events. By this time, there are several reports that type 2 diabetic subjects have higher serum levels of hsCRP than those of non-diabetic subjects. However, there are few reports about factors which have influence upon the level of serum hsCRP in type 2 diabetic subjects. We had evaluated the association of serum hsCRP level with risk factors of cardiovascular diseases and carotid intima-media thickness (IMT) in type 2 diabetic subjects. METHODS: One hundred and five patients (59 men and 46 women) with type 2 diabetes were recruited. Subjects with severe cardiovascular diseases were excluded. All subjects were undergone carotid ultrasonography for evaluation of carotid IMT. Serum hsCRP concentrations were measured. RESULTS: Serum hsCRP level was correlated with mean left IMT (r = 0.366, P = 0.003), maximal left IMT (r = 0.370, P = 0.002), mean right IMT (r = 0.281, P = 0.023) and maximal right IMT (r = 0.370, P = 0.002), body mass index (r = 0.377, P < 0.001), waist circumference (r = 0.342, P < 0.001), waist-hip ratio (r = 0.229, P = 0.020), serum total cholesterol (r = 0.202, P = 0.024), serum triglyceride (r = 0.292, P = 0.022) and serum low-density lipoprotein (r = 0.133, P = 0.044). CONCLUSION: Our result shows that serum hsCRP level is correlated with carotid IMT and the risk factors of cardiovascular diseases and may be useful to predict accelerated atherosclerotic process in type 2 diabetic subjects.
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Hyung Jin(김형진)
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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