Cited 8 times in
Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.date.accessioned | 2015-07-14T16:47:52Z | - |
dc.date.available | 2015-07-14T16:47:52Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111609 | - |
dc.description.abstract | PURPOSE: Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model. METHODS: About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group, n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (n = 5). Statistical analysis was done with an independent t-test. RESULTS: Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (P = .03) and LDH (P = .05) levels were significantly lower in the gadolinium group. CONCLUSION: Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1928~1930 | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Gadolinium/therapeutic use* | - |
dc.subject.MESH | Kupffer Cells/drug effects | - |
dc.subject.MESH | Kupffer Cells/pathology | - |
dc.subject.MESH | L-Lactate Dehydrogenase/blood | - |
dc.subject.MESH | Liver Function Tests | - |
dc.subject.MESH | Liver Transplantation/methods* | - |
dc.subject.MESH | Liver Transplantation/physiology* | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | K.Y. Chung | - |
dc.contributor.googleauthor | G.Y. Jeong | - |
dc.contributor.googleauthor | Y.S. Kim | - |
dc.contributor.googleauthor | S.H. Sung | - |
dc.contributor.googleauthor | K.B. Choi | - |
dc.identifier.doi | 10.1016/j.transproceed.2004.09.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 15518701 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041134504010668 | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1928 | - |
dc.citation.endPage | 1930 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, Vol.36(7) : 1928-1930, 2004 | - |
dc.identifier.rimsid | 37363 | - |
dc.type.rims | ART | - |
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