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Additive effect of the mutations in the beta3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-07-14T16:45:18Z | - |
dc.date.available | 2015-07-14T16:45:18Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111523 | - |
dc.description.abstract | OBJECTIVE: To analyze the effects of the mutations in the beta3-adrenoceptor (beta3-AR) gene and/or uncoupling protein3 (UCP3) gene promoter on body fat distribution and glycemic control after mild weight reduction in overweight-obese subjects with coronary artery disease (CAD) or metabolic syndrome. DESIGN: Clinical intervention study of the -300 kcal/day mild weight reduction program for 12 weeks. SUBJECTS: A total of 224 overweight-obese subjects with CAD or metabolic disorder, subdivided into the following four categories: (1) wild type (TT-CC, n=73); (2) only UCP3 promoter variant (TT-CT/TT, n=90); (3) only beta3-AR variant (TA/AA-CC, n=29); (4) both variants (TA/AA-CT/TT, n=32). MEASUREMENT: Body mass index (BMI), blood pressure, calorie intakes, body fat distribution, serum glucose, insulin, free fatty acids, C-peptide and lipids before and after weight reduction. RESULTS: After 12 weeks, all subjects lost approximately 5% of their initial body weight. Despite similar weight reduction, the highest decreases in abdominal adipose tissue at both L1 and L4 levels were observed in the 'wild-type' group (P<0.001) and the second highest in 'only UPC3 promoter variant' group (P<0.001). On the other hand, both variant-carriers had the smallest reduction only in visceral fat area at the L4 level. All subjects except both variant-carriers showed significant reductions in the fasting levels of glucose and FFA. The response areas of glucose (P<0.01) and insulin (P<0.05) were reduced largest in the 'wild-type' group and second largest in the 'UCP3 promoter variant' group. CONCLUSION: All the four groups showed similar weight reduction after -300 kcal/d for 12 weeks. However, the beneficial effects on body fat distribution and glycemic control were greatest in the 'wild-type' group and smallest in 'both variants' group. In addition, these effects were less beneficial in carriers with beta3-AR gene variant than with UCP3 gene promoter variant. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 434~441 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF OBESITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/pathology* | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Carrier Proteins/genetics* | - |
dc.subject.MESH | Coronary Disease/blood | - |
dc.subject.MESH | Coronary Disease/genetics | - |
dc.subject.MESH | Diet, Reducing | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ion Channels | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/blood | - |
dc.subject.MESH | Metabolic Syndrome/genetics | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitochondrial Proteins | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Obesity/diet therapy | - |
dc.subject.MESH | Obesity/genetics* | - |
dc.subject.MESH | Obesity/pathology | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Receptors, Adrenergic, beta-3/genetics* | - |
dc.subject.MESH | Uncoupling Protein 3 | - |
dc.subject.MESH | Weight Loss | - |
dc.title | Additive effect of the mutations in the beta3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | O Y Kim | - |
dc.contributor.googleauthor | E Y Cho | - |
dc.contributor.googleauthor | H Y Park | - |
dc.contributor.googleauthor | Y Jang | - |
dc.contributor.googleauthor | J H Lee | - |
dc.identifier.doi | 10.1038/sj.ijo.0802562 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01140 | - |
dc.identifier.eissn | 1476-5497 | - |
dc.identifier.pmid | 14708035 | - |
dc.identifier.url | http://www.nature.com/ijo/journal/v28/n3/full/0802562a.html | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 434 | - |
dc.citation.endPage | 441 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF OBESITY, Vol.28(3) : 434-441, 2004 | - |
dc.identifier.rimsid | 34894 | - |
dc.type.rims | ART | - |
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