Cited 11 times in
Relationship between Epstein-Barr virus-encoded RNA expression, apoptosis and lymphocytic infiltration in gastric carcinoma with lymphoid-rich stroma
DC Field | Value | Language |
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dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2015-07-14T16:45:09Z | - |
dc.date.available | 2015-07-14T16:45:09Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1011-7571 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111518 | - |
dc.description.abstract | OBJECTIVE: To investigate the association of apoptosis with apoptotic proteins and Epstein-Barr virus (EBV) expression in gastric carcinoma with lymphoid-rich stroma (GCLRS) in order to clarify the relationship between lymphocytic infiltration, EBV expression and apoptosis in gastric carcinoma. SUBJECTS and METHODS: We performed immunohistochemical stains for bcl-2, bax and in situ hybridization for EBV-encoded RNA and the terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling technique using the 24 cases of GCLRS and 23 cases of gastric carcinoma with lymphoid-poor stroma (GCLPS) out of 1,635 cases of gastric carcinoma. RESULTS: The prevalence of GCLRS was 1.47% (24/1,635). The prevalence of EBV involvement in GCLRS (79%, 19/24) was significantly higher than in GCLPS (8.7%, 2/23). Apoptosis was revealed in all cases and there was no statistical difference between GCLRS and GCLPS. Immunohistochemical expression for bcl-2 was revealed only in the cytoplasm of lymphocytes in all cases, but bax showed distinct expression in the cytoplasm of neoplastic cells in all cases. There was a significant correlation between bax expression and the apoptotic index (p <0.05). Lymphocytic infiltration was significantly correlated with the expression of EBV (p <0.05) but not with survival rate and apoptosis. Most of the GCLRS cases were rated as low clinical stage (stage IA or B) and seemed to have a good prognosis. CONCLUSIONS: These results support the hypothesis that EBV infection plays an important role in the tumorigenesis of GCLRS, which has a better prognosis than usual gastric adenocarcinoma although there was no significant difference in the apoptotic index between GCLRS and GCLPS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 353~360 | - |
dc.relation.isPartOf | MEDICAL PRINCIPLES AND PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/virology* | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Epstein-Barr Virus Infections/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/metabolism | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/metabolism | - |
dc.subject.MESH | RNA, Viral/analysis* | - |
dc.subject.MESH | Staining and Labeling | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/virology* | - |
dc.title | Relationship between Epstein-Barr virus-encoded RNA expression, apoptosis and lymphocytic infiltration in gastric carcinoma with lymphoid-rich stroma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Cho M.-Y. | - |
dc.contributor.googleauthor | Kim T.H. | - |
dc.contributor.googleauthor | Park K.H. | - |
dc.contributor.googleauthor | Jung W.H. | - |
dc.contributor.googleauthor | Yi S.Y. | - |
dc.identifier.doi | 10.1159/000080473 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02209 | - |
dc.identifier.eissn | 1423-0151 | - |
dc.identifier.pmid | 15467311 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/80473 | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | Stomach | - |
dc.subject.keyword | Gastric carcinoma with lymphoid-rich stroma | - |
dc.subject.keyword | Epstein-Barr virus | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | bcl-2 | - |
dc.subject.keyword | bax | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 353 | - |
dc.citation.endPage | 360 | - |
dc.identifier.bibliographicCitation | MEDICAL PRINCIPLES AND PRACTICE, Vol.13(6) : 353-360, 2004 | - |
dc.identifier.rimsid | 34891 | - |
dc.type.rims | ART | - |
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