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Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: Resistance mechanism to transforming growth factor-β
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 박찬일 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2015-07-14T16:44:33Z | - |
dc.date.available | 2015-07-14T16:44:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0172-6390 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111498 | - |
dc.description.abstract | BACKGROUND/AIMS: Smad7 is an inhibitory Smad of the transforming growth factor (TGF)-beta signaling pathway. To study resistance mechanisms to antiproliferating effect of TGF-beta in human multistep hepatocarcinogenesis, Smad7, Smad4, TGF-beta1 and TGF-beta receptor II were investigated. METHODOLOGY: Smad7 and Smad4 were evaluated in 15 low-grade dysplastic nodules (DNs), 9 high-grade DNs, 6 early hepatocellular carcinomas (eHCCs) and 41 advanced HCCs by immunohistochemistry and in 37 HCCs and corresponding non-HCCs with fresh tissue, the mRNAs of TGF-beta1 and TGF-beta receptor II were analyzed by RT-PCR. RESULTS: Smad7 immunoreactivity in tumor cells was found in 25 (61%) advanced HCCs, in contrast to none of DNs and eHCCs. Smad7 expression was significantly higher in advanced HCCs with increased TGF-beta1 or no decrease of TGF-beta receptor II compared to those of corresponding non-HCCs (p=0.044, p=0.027). Smad4 expression in stellate cells was present in 28 (68%) advanced HCCs, which was higher in smaller sized and better differentiated HCCs. CONCLUSIONS: Smad7, expressed in tumor cells, is considered to be one of resistance mechanisms to increased TGF-beta1 in late stage hepatocarcinogenesis, especially in advanced HCCs without reduced TGF-beta receptor II. Smad4, in stellate cells of HCCs, might be involved in the host resistance to hepatocarcinogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 396~400 | - |
dc.relation.isPartOf | HEPATO-GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism* | - |
dc.subject.MESH | DNA-Binding Proteins/metabolism* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis/metabolism | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Transforming Growth Factor beta/physiology | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Smad4 Protein | - |
dc.subject.MESH | Smad7 Protein | - |
dc.subject.MESH | Trans-Activators/metabolism* | - |
dc.subject.MESH | Transforming Growth Factor beta/physiology* | - |
dc.title | Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: Resistance mechanism to transforming growth factor-β | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Kwang Jo Chae | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Kyeong Sook Choi | - |
dc.contributor.googleauthor | Jinsub Choi | - |
dc.contributor.googleauthor | Bong-Kyeong Oh | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00984 | - |
dc.identifier.pmid | 15086168 | - |
dc.identifier.url | http://www.hepatogastroenterology.org/index.php/withdrawals/item/4365-expression-of-smad7-in-hepatocellular-carcinoma-and-dysplastic-nodules-resistance-mechanism-to-transforming-growth-factor-%25CE%25B2 | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Chan Il | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 51 | - |
dc.citation.number | 56 | - |
dc.citation.startPage | 396 | - |
dc.citation.endPage | 400 | - |
dc.identifier.bibliographicCitation | HEPATO-GASTROENTEROLOGY, Vol.51(56) : 396-400, 2004 | - |
dc.identifier.rimsid | 34877 | - |
dc.type.rims | ART | - |
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