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Risk of ovarian failure and pregnancy outcome in patients with lupus nephritis treated with intravenous cyclophosphamide pulse therapy

DC Field Value Language
dc.contributor.author박민찬-
dc.contributor.author박용범-
dc.contributor.author이수곤-
dc.contributor.author정상윤-
dc.contributor.author정일형-
dc.contributor.author최규헌-
dc.date.accessioned2015-07-14T16:43:15Z-
dc.date.available2015-07-14T16:43:15Z-
dc.date.issued2004-
dc.identifier.issn0961-2033-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111455-
dc.description.abstractThis study was designed to investigate the risk of ovarian failure and the pregnancy outcomes in women treated with intravenous cyclophosphamide (IVCYC) pulse therapy for lupus nephritis. Sixty-seven women with proliferative lupus nephritis were studied. The clinical and laboratory data, SLEDAI and damage indices at IVCYC initiation, doses and numbers of IVCYC pulses, pregnancy and fetal outcomes were evaluated. During a follow-up of 74.4+/-20.6 months, amenorrhea occurred in 25 (37.3%) and was sustained permanently in 10 patients (14.9%). Thirteen women became pregnant with a total of 19 pregnancies. Seventeen pregnancies ended without complications and all babies were born healthy without any congenital anomalies or perinatal illnesses. Two pregnancies were terminated by induced abortion but no congenital anomaly was noted in these cases. Logistic regression analysis showed that old age, high damage index at the initiation of IVCYC pulse therapy and high cumulative dosage of IVCYC were the independent risk factors of ovarian failure, and that the presence of amenorrhea, regardless of its duration, was the risk factor of pregnancy failure. Pregnancy was possible with a favorable outcome after the withdrawal of IVCYC pulse therapy, unless amenorrhea develops.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLUPUS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAmenorrhea/chemically induced-
dc.subject.MESHCyclophosphamide/administration & dosage-
dc.subject.MESHCyclophosphamide/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/administration & dosage-
dc.subject.MESHImmunosuppressive Agents/adverse effects*-
dc.subject.MESHInfertility, Female/chemically induced-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHLupus Nephritis/drug therapy*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy Complications*-
dc.subject.MESHPregnancy Outcome-
dc.subject.MESHPrimary Ovarian Insufficiency/chemically induced*-
dc.subject.MESHPulse Therapy, Drug-
dc.subject.MESHRisk Factors-
dc.titleRisk of ovarian failure and pregnancy outcome in patients with lupus nephritis treated with intravenous cyclophosphamide pulse therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorM-C Park-
dc.contributor.googleauthorY-B Park-
dc.contributor.googleauthorS-K Lee-
dc.contributor.googleauthorKH Choi-
dc.contributor.googleauthorIH Chung-
dc.contributor.googleauthorSY Jung-
dc.identifier.doi10.1191/0961203304lu1063oa-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02175-
dc.identifier.eissn1477-0962-
dc.identifier.pmid15462485-
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1191/0961203304lu1063oa-
dc.subject.keywordamenorrhea-
dc.subject.keywordcyclophosphamide-
dc.subject.keywordlupus nephritis-
dc.subject.keywordovarian failure-
dc.subject.keywordpregnancy-
dc.contributor.alternativeNamePark, Min Chan-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameJung, Sang Youn-
dc.contributor.alternativeNameChung, Il Hyung-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.rights.accessRightsnot free-
dc.citation.volume13-
dc.citation.number8-
dc.citation.startPage569-
dc.citation.endPage574-
dc.identifier.bibliographicCitationLUPUS, Vol.13(8) : 569-574, 2004-
dc.identifier.rimsid35827-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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