Cited 21 times in
Redox Signaling by Ionizing Radiation in Mouse Liver
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2015-07-14T16:41:27Z | - |
dc.date.available | 2015-07-14T16:41:27Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111394 | - |
dc.description.abstract | Since radiation treatment has been reappraised in the treatment of hepatic tumors, radiation response in the liver is emerging as an interesting new area of investigation. In this study, identification of the repertoire of signaling proteins was performed using a proteomics approach involving cellular responses of liver tissue to ionizing radiation. Approximately 800 protein spots were detected. Among them, at least 28 proteins showed significant quantitative alterations after radiation. The significantly altered proteins were categorized as those related to reactive oxygen species (ROS) metabolism, metabolic pathway proteins, and G-type proteins. Particularly, the expression levels of proteins related to ROS metabolism, including cytochrome c, glutathione S-transferase Pi, NADH dehydrogenase, and peroxiredoxin VI, were increased after radiation. It is suggested that although radiation initiates cytotoxic effects, it can also induce a radioprotective antioxidant system. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 86~94 | - |
dc.relation.isPartOf | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Electrophoresis, Gel, Two-Dimensional | - |
dc.subject.MESH | Glutathione Transferase/metabolism | - |
dc.subject.MESH | Liver/enzymology | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Liver/radiation effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C3H | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | Proteomics | - |
dc.subject.MESH | Radiation, Ionizing* | - |
dc.subject.MESH | Signal Transduction/radiation effects* | - |
dc.title | Redox Signaling by Ionizing Radiation in Mouse Liver | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | JEUNG HEE AN | - |
dc.contributor.googleauthor | JIYOUNG KIM | - |
dc.contributor.googleauthor | JINSIL SEONG | - |
dc.identifier.doi | 10.1196/annals.1329.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00181 | - |
dc.identifier.eissn | 1749-6632 | - |
dc.identifier.pmid | 15659784 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1196/annals.1329.011/abstract | - |
dc.subject.keyword | liver | - |
dc.subject.keyword | ionizing radiation | - |
dc.subject.keyword | antioxidant enzyme | - |
dc.subject.keyword | reactive oxygen species | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 1030 | - |
dc.citation.startPage | 86 | - |
dc.citation.endPage | 94 | - |
dc.identifier.bibliographicCitation | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1030 : 86-94, 2004 | - |
dc.identifier.rimsid | 35788 | - |
dc.type.rims | ART | - |
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